Hypericum perforatum chronic treatment affects cognitive parameters and brain neurotrophic factor levels

Objective: To evaluate the effects of Hypericum perforatum (hypericum) on cognitive behavior and neurotrophic factor levels in the brain of male and female rats. Methods: Male and female Wistar rats were treated with hypericum or water during 28 days by gavage. The animals were then subjected to the open-field test, novel object recognition and step-down inhibitory avoidance test. Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-line derived neurotrophic factor (GDNF) levels were evaluated in the hippocampus and frontal cortex. Results: Hypericum impaired the acquisition of short- and long-term aversive memory in male rats, evaluated in the inhibitory avoidance test. Female rats had no immediate memory acquisition and decreased short-term memory acquisition in the inhibitory avoidance test. Hypericum also decreased the recognition index of male rats in the object recognition test. Female rats did not recognize the new object in either the short-term or the long-term memory tasks. Hypericum decreased BDNF in the hippocampus of male and female rats. Hypericum also decreased NGF in the hippocampus of female rats. Conclusions: The long-term administration of hypericum appears to cause significant cognitive impairment in rats, possibly through a reduction in the levels of neurotrophic factors. This effect was more expressive in females than in males.

Blood pressure pattern and the relationship with body mass index among apparently healthy secondaryschool students in Sokoto metropolis, Nigeria

Background. Childhood obesity may result in the premature onset of cardiovascular risk factors, particularly hypertension, hence the need for proper screening. However, blood pressure (BP) is measured only once in most studies in Nigeria, probably because of difficulties in returning to the study areas for repeat measurement.Objective. To determine the BP pattern and assess its relationship with body mass index (BMI) in apparently healthy secondary-school students aged 10 - 18 years in Sokoto metropolis, Nigeria.Methods. This study was descriptive and cross-sectional, and carried out between 13 October 2014 and 30 January 2015. In total, 800students from 6 schools were selected through multistage sampling. BP was measured on three separate days according to the National High Blood Pressure Education Program charts. BMI was categorised according to the Centers for Disease Control charts. The relationship of BP level with BMI was determined.Results. There were 424 (53.0%) males and 376 (47.0%) females, with a ratio of approximately 1:1. BP increased with age. The mean systolic and diastolic BP was significantly higher in females than males (systolic 113.1 mmHg v. 110.5 mmHg, and diastolic 69.0 mmHg v. 66.5 mmHg, respectively; p=0.01). Females had a higher mean BMI than males (18.7 kg/m2 v. 17.9 kg/m2, respectively; p<0.01). BP increased as the BMI percentile increased (p<0.001). The prevalence rates of hypertension were 6.1%, 3.5% and 3.1% at the first, second and third screenings, respectively, while the corresponding prevalence rates of prehypertension were 14.3%, 8.4% and 7.1%. The prevalence of obesity and overweight was 0.3% and 5.9%, respectively.Conclusion. The prevalence rate of prehypertension and hypertension reduced with subsequent measurements, and the prevalence rates of overweight and obesity were low. However, higher BP levels were associated with higher BMI, supporting its predictive significance for elevated BP

Effects of electro-acupuncture at Tongli (HT 5) and Xuanzhong (GB 39) acupoints from functional magnetic resonance imaging evidence / 中国结合医学杂志

<p><b>OBJECTIVE</b>To explore the specifificity of Tongli (HT 5) and Xuanzhong (GB 39) paired acupionts in aspects of Deqi sensation and brain activation patterns during electroacupuncture.</p><p><b>METHODS</b>In this study, 15 healthy subjects were enrolled. All participants suffered two kinds of functional magnetic resonance imaging (fMRI) examinations randomly: Examination A received electro-acupuncture (EA) at the bilateral Tongli (HT5) and Xuanzhong (GB 39) acupoints (ACU), and examination B received EA at bilateral non-acupoints (NAP). The subjects reported the feeling of Deqi at each examination later respectively. A multi-voxel pattern analysis method and Statistical Program for Social Sciences were used to analyze the data.</p><p><b>RESULTS</b>The ACU group (Exam A) reported fullness, heaviness, numbness, soreness and throbbing of signifificantly greater intensity than the NAP group (Exam B). In addition, there was no statistical signifificance between two groups in aching, tingling, deep pressure, sharp pain, dull pain, warmness and cold. Meanwhile, fMRI data revealed differences between two groups in discriminating accuracy of brain somatosensory cortex and language-related cortices.</p><p><b>CONCLUSIONS</b>Needling HT 5 and GB 39 may modulate language function through a complex brain network, suggesting that it may be benefificial to the recovery of language function in patients with aphasia.</p>

Reconhecimento de cores de objetos e de alimentos de cromaticidades opostas por pintos de corte / Recognition of colors of objects and food opposite chromaticities by broiler chicks

Objetivou-se com esta pesquisa avaliar, por meio de testes de preferência, a capacidade de percepção de pintos de corte no reconhecimento de objetos e alimentos de diferentes cores. A pesquisa foi realizada no Brasil e consistiu no condicionamento de 60 pintos de um dia sexados, sendo 30 pintos machos e 30 pintos fêmeas, durante três dias, com esferas azuis e alimento vermelho, cores escolhidas por terem cromaticidades opostas. Após a fase de condicionamento, foi realizado um teste de preferência, no qual os animais eram colocados individualmente no centro de uma arena de teste com quatro opções, sendo elas: alimento vermelho; alimento azul; esferas vermelhas; esferas azuis. Cada ave foi avaliada durante 10 minutos...

The aim of this research was to evaluate, by preference tests, the ability of perception of broiler chicks in the recognition of objects and foods of different colors. The survey was conducted in Brazil and consisted in the conditioning of 60 sexed one-day-old chicks using 30 male chicks and 30 female chicks for three days with blue balls and red food colors chosen for having opposed chromaticities. After the conditioning phase, a preference test was performed, in which the animals were placed individually in the center of an arena test with four options: red food, blue food, red balls and blue balls. Each bird was measured for 10 minutes...

Channel Selection for Multi-class Motor Imagery Based on Common Spatial Pattern / 生物医学工程学杂志

High-density channels are often used to acquire electroencephalogram (EEG) spatial information in different cortical regions of the brain in brain-computer interface (BCI) systems. However, applying excessive channels is inconvenient for signal acquisition, and it may bring artifacts. To avoid these defects, the common spatial pattern (CSP) algorithm was used for channel selection and a selection criteria based on norm-2 is proposed in this paper. The channels with the highest M scores were selected for the purpose of using fewer channels to acquire similar rate with high density channels. The Dataset III a from BCI competition 2005 were used for comparing the classification accuracies of three motor imagery between whole channels and the selected channels with the present proposed method. The experimental results showed that the classification accuracies of three subjects using the 20 channels selected with the present method were all higher than the classification accuracies using all 60 channels, which convinced that our method could be more effective and useful.

Biometric identification method for ECG based on the piecewise linear representation (PLR) and dynamic time warping (DTW) / 生物医学工程学杂志

To treat the problem of identification performance and the complexity of the algorithm, we proposed a piecewise linear representation and dynamic time warping (PLR-DTW) method for ECG biometric identification. Firstly we detected R peaks to get the heartbeats after denoising preprocessing. Then we used the PLR method to keep important information of an ECG signal segment while reducing the data dimension at the same time. The improved DTW method was used for similarity measurements between the test data and the templates. The performance evaluation was carried out on the two ECG databases: PTB and MIT-BIH. The analystic results showed that compared to the discrete wavelet transform method, the proposed PLR-DTW method achieved a higher accuracy rate which is nearly 8% of rising, and saved about 30% operation time, and this demonstrated that the proposed method could provide a better performance.

Facial emotional recognition in schizophrenia: preliminary results of the virtual reality program for facial emotional recognition / Reconhecimento emocional de faces na esquizofrenia: resultados preliminares do programa de realidade virtual para o reconhecimento emocional de faces

BACKGROUND: Significant deficits in emotional recognition and social perception characterize patients with schizophrenia and have direct negative impact both in inter-personal relationships and in social functioning. Virtual reality, as a methodological resource, might have a high potential for assessment and training skills in people suffering from mental illness. OBJECTIVES: To present preliminary results of a facial emotional recognition assessment designed for patients with schizophrenia, using 3D avatars and virtual reality. METHODS: Presentation of 3D avatars which reproduce images developed with the FaceGen® software and integrated in a three-dimensional virtual environment. Each avatar was presented to a group of 12 patients with schizophrenia and a reference group of 12 subjects without psychiatric pathology. RESULTS: The results show that the facial emotions of happiness and anger are better recognized by both groups and that the major difficulties arise in fear and disgust recognition. Frontal alpha electroencephalography variations were found during the presentation of anger and disgust stimuli among patients with schizophrenia. DISCUSSION: The developed program evaluation module can be of surplus value both for patient and therapist, providing the task execution in a non anxiogenic environment, however similar to the actual experience.

CONTEXTO: Pessoas diagnosticadas com esquizofrenia apresentam um défice significativo na cognição social com implicações negativas relativamente ao funcionamento interpessoal e social. A realidade virtual apresenta grandes potencialidades para a avaliação e o treino de competências em pessoas com doença mental. OBJETIVOS: Apresentar os resultados preliminares de um programa construído para avaliação do reconhecimento emocional de faces por pessoas com esquizofrenia, utilizando avatares 3D e realidade virtual. MÉTODOS: Apresentação de avatares 3D que reproduzem expressões emocionais, construídas por meio do FaceGen® e integradas num ambiente virtual tridimensional. Apresentou-se cada avatar a 12 doentes com esquizofrenia e a 12 pessoas sem patologia psiquiátrica, avaliando as respostas de reconhecimento e a atividade eletroencefalográfica frontal. RESULTADOS: Os resultados demonstraram que as expressões de alegria e raiva foram as mais bem reconhecidas pelos dois grupos, enquanto de medo e nojo foram as de maior dificuldade. Verificaram-se alterações na atividade alfa frontal para os estímulos raiva e nojo na amostra de doentes com esquizofrenia. CONCLUSÃO: Apesar de algumas expressões emocionais poderem ser melhoradas, o programa desenvolvido pode constituir uma mais-valia para o paciente e para o terapeuta, proporcionando a execução da tarefa em condições não ansiogênicas e aproximadas à experiência real.

Procesamiento emocional en la vejez / Emotional processing in old age

Se cita la etimología de la palabra emoción, la evolución histórica de las diferentes teorías de esta y se profundiza en la Teoría de las emociones de A. Damasio, quien clasifica las emociones como: de fondo, primarias y secundarias, describe el procesamiento emocional, diferencia y define emoción de sentimiento. El planteo es ¿procesan igual las emociones los adultos mayores que los jóvenes?, si fuera así, ¿qué beneficios les traería? Se revisaron trabajos neurobiológicos que muestran un mejor procesamiento de las emociones positivas que de las negativas en la vejez sana a través de estudios con RMCf (Resonancia Magnética de Cerebro funcional). Se cita la Teoría de la selectividad socioemocional. En 1993, L. Carstensen postula que con el envejecimiento se produce un cambio motivacional por el cual las personas jerarquizan las metas, su significado y la optimizacion de su experiencia. Frente a eventos vitales negativos (enfermedades, pérdidas afectivas, etc. las personas mayores siguen manteniendo niveles similares o superiores de bienestar subjetivo es la Paradoja del bienestar en la vejez. Se analizan trabajos sobre emociones y enfermedad de Alzheimer.

The etymology of the word "emotion" is explained as well as its evolution throughout the years. Antonio Damasio's classification of backgrounds, primary and secondary emotions are described along with its differences in moaning with the word "feeling". Two differences in emotional Procedure between older and young adults are mentions. RMCf was shown a better positive emotional processing in old age. From Social Theories, Selectivity, Hierarchical organization of goals, paradox in the elderly, emotional balance, and subjective dimensions and shown. The relationship between these change and life quality during normal and pathological aging as well as Alzheimer's disease is also mentions.

Study of biometric identification of heart sound base on Mel-Frequency cepstrum coefficient / 生物医学工程学杂志

Heart sound is a physiological parameter with individual characteristics generated by heart beat. To do the individual classification and recognition, in this paper, we present our study of using wavelet transform in the signal denoising, with the Mel-Frequency cepstrum coefficients (MFCC) as the feature parameters, and propose a research of reducing the dimensionality through principal components analysis (PCA). We have done the preliminary study to test the feasibility of biometric identification method using heart sound. The results showed that under the selected experimental conditions, the system could reach a 90% recognition rate. This study can provide a reference for further research.

A study to evaluate the effect of oral stereognosis in acceptance of fixed prosthesis.

Aims: The aim of the study was to evaluate and compare the oral stereognostic ability and satisfaction for fixed prosthesis in human being. Materials and Methods: The present study was carried out on 40 subjects, the purpose being to investigate the relation of oral perception to diagnostic and therapeutic procedures. Two types of cast metal crowns-one had morphology closely resembling original tooth and other one confirmed to ideal contours were constructed on endodontically treated posterior tooth. One cast metal crown was randomly selected from two cast metal crown and fitted on prepared tooth. Oral stereognostic score of subject was determined by correct response to questionnaire based on the recognition ability of subjects. Patient satisfaction level was checked by psychometric parameter Likert scale. Same procedure was repeated with other type of cast metal crown. Results: Data obtained were compared by paired and unpaired two sample t-test. Oral stereognostic score and satisfaction score were found to be higher for cast metal crown with morphology resembling to original tooth due to recognition and discriminatory ability of subjects and recall-memory. Oral stereognostic level was found to be higher in younger than older subjects. The level of satisfaction was found to be higher in older subjects than younger subjects. Conclusion: It was concluded that acceptance of fixed prosthesis is not only based on dentist's routine procedure of treatment and patient's judgment about oral health, function, and esthetics, but also depends upon patient's oral perception and discriminatory skill for external morphology of fixed prosthesis.

Búsqueda de alimento en hámsteres dorados(Mesocricetus auratus): el efecto de la distancia entre múltiples fuentes de alimento / Foraging behavior in golden hamsters (Mesocricetus auratus): effect of the distance among multiple patches

Se evaluó el patrón de desplazamiento y la eficiencia en la búsqueda de alimento de cuatro hámsteres en un encierro con múltiples metas, variando la distancia entre ellas. La distancia entre las metas se manipuló en orden aleatorio, según dos condiciones: la de Metas Cercanas (10 cm entre ellas) y la condición de Metas Distantes (21.5 cm entre ellas). Los sujetos debían extraer el alimento colocado dentro de unos cilindros (estaciones) trepando a ellos en un encierro de 110 cm2. Los resultados mostraron, en ambas condiciones, que la distancia recorrida entre las subidas a las estaciones fue mayor en momentos más tardíos del ensayo. Por otro lado, aunque la proporción más alta de elecciones se centró en las estaciones adyacentes, éstas ocurrieron en mayor medida para la condición de Estaciones Distantes, y hubo un mayor número de elecciones a estaciones ubicadas diagonalmente o salteadas en la condición de Estaciones Cercanas.

The pattern of travel and the efficiency in foraging behavior was evaluated in four hamsters searching for food within an enclosure with multiple patches. Two different distances among patches were randomly arranged: Near-Patches (10 cm separation) and Distant-Patches (21.5 cm separation). Subjects obtained the food by mounting over the cylinders (stations) placed in the enclosure of 110 cm2. Results showed that in both, Near and Distant conditions, the distance between responses was longer in late stages of the trials then in early stages. Nonetheless, the most choices to adjacent stations were in Distant-Patches condition, while skips and diagonal-station choices were more frequently showed in the Near-Patches condition.

Avaliação do padrão de duração no teste de próteses auditivas / Evaluation of the pattern duration in hearing aids testing

Várias pesquisas já foram realizadas na intenção de investigar o processo de adaptação de aparelhos auditivos. Atualmente, os estudos referentes ao processamento auditivo podem contribuir com tal processo. Avaliar o desempenho dos pacientes no teste do padrão de duração a testagem de aparelhos auditivos analógicos e digitais. A coleta de dados realizada ao período...

Several researches have already been done to investigate the adaptation process of hearing aids. Currently, the referring studies to the auditory processing can contribute to such process...

Analysis and research of brain-computer interface experiments for imaging left-right hands movement / 生物医学工程学杂志

This is a research carried out to explore a pragmatic way of BCI based imaging movement, i. e. to extract the feature of EEG for reflecting different thinking by searching suitable methods of signal extraction and recognition algorithm processing, to boost the recognition rate of communication for BCI system, and finally to establish a substantial theory and experimental support for BCI application. In this paper, different mental tasks for imaging left-right hands movement from 6 subjects were studied in three different time sections (hint keying at 2s, 1s and 0s after appearance of arrow). Then we used wavelet analysis and Feed-forward Back-propagation Neural Network (BP-NN) method for processing and analyzing the experimental data of off-line. Delay time delta t2, delta t1 and delta t0 for all subjects in the three different time sections were analyzed. There was significant difference between delta to and delta t2 or delta t1 (P<0.05), but no significant difference was noted between delta t2 and delta t1 (P>0.05). The average results of recognition rate were 65%, 86.67% and 72%, respectively. There were obviously different features for imaging left-right hands movement about 0.5-1s before actual movement; these features displayed significant difference. We got higher recognition rate of communication under the hint keying at about 1s after the appearance of arrow. These showed the feasibility of using the feature signals extracted from the project as the external control signals for BCI system, and demon strated that the project provided new ideas and methods for feature extraction and classification of mental tasks for BCI.

Correlations between event-related potentials with pictures recognition and WMS-RC scores in patients with memory disorder caused by severe traumatic brain injury / 华中科技大学学报（医学）（英德文版）

This study explored the possibility of using event-related potentials (ERP) for the measurement of picture-recognition memory and examined its correlation with the Chinese Wechsler Memory Scale-revised (WMS-RC) in patients with memory disorder caused by severe traumatic brain injury (sTBI). The subjects included 20 sTBI patients with memory disorder and 22 healthy individuals. Memory function was measured by using WMS-RC. Behavioral and ERP responses were recorded on-line during performance on a battery of picture recognition and the responses were analyzed off-line for recognition memory effects. Mean memory quotient (MQ) of patients with sTBI was significantly lower than that of the control group. Mean reaction time (RT) was significantly longer and the mean correctness rate (CR) of picture recognition was significantly lower in sTBI group than that of the controls. In controls, the main components of average ERP of picture recognition includes two positive-going waves, designated as P(170) and P(500), that appear 170 ms and 500 ms after stimulation when the subject could later successfully recall and recognize the pictures. P(500) amplitude of target stimulus was significantly higher than that of non-target stimulus. Compared to controls, P(500) responses of sTBI group were significantly delayed in latency (P<0.001) and lower in amplitude (P<0.001). P(500) latency showed significant negative correlation with MQ and the scores of "addition", "visual recognition", "picture recall", "visual reproduction" and "tactile memory" in WMS-RC. ERP of picture recognition provides a neurophysiological approach to directly assess memory impairment, and P(500) may serve as a helpful index for memory disorder caused by sTBI in forensic practice.

A review on the applications of acoustic analysis in diagnosing disease / 生物医学工程学杂志

Acoustic analysis is one of the important branches of biometric recognition technology widely used now. The mainly aim of the technology is to recognize the identity of person and judge the content of speech or diagnose the illness automatically according to the features extracted from the speaker's waveforms. All these features are related with the characteristics of speaker's physiological, pathological and psychological action. Speaker recognition study has its 50-year old history already, but acoustic analysis in diagnosing disease has been founded since 1970s. This paper introduces the main concept and research background of this diagnosing system generally and discusses the problems generated during processing. At last the prospect for the applications of acoustic analysis is forecasted.