Résumé
Under the catalysis of a variety of metabolic enzymes in vivo, such as UDP-glucuronyl transferases, cytochrome P450, carboxylesterase, sulfotransferase, butyrylcholinesterase, catechol-O-methyl transferase and 6-morphine dehydrogenase, the drugs perform glucuronidation, hydrolysis, oxidation, sulfonation and other reactions, then translate into active or inactive metabolites, which are excreted through urination, bile or the other pathways at last. Different drugs own their different metabolic pathways. This paper introduces the studies about the metabolism of drugs in human and animal in recent years, such as morphine-like drugs, amphetamine, ketamine, cannabis and cocaine, and reviews the research progress about the sites of metabolism, metabolic enzymes, metabolites and physiological activity of those drugs metabolic in vivo.
Sujets)
Animaux , Humains , Alcohol oxidoreductases/métabolisme , Carboxylesterase/métabolisme , Catechol O-methyltransferase/métabolisme , Cholinesterases/métabolisme , Cytochrome P-450 enzyme system/métabolisme , Glucuronosyltransferase/métabolisme , Substances illicites/métabolisme , Oxydoréduction , Sulfotransferases/métabolismeSujets)
Humains , Substances illicites/métabolisme , Infections à VIH/induit chimiquement , Infections à VIH/thérapie , Promotion de la santé , Syndrome d'immunodéficience acquise/induit chimiquement , Syndrome d'immunodéficience acquise/thérapie , Relations entre professionnels de santé et patients , Thérapie antirétrovirale hautement activeRésumé
Noções básicas sobre as principais drogas são apresentadas em linguagem didática, reforçada por ilustrações e leituras adicionais. A adequada informação abre caminho para a discussão e a reflexão, práticas capazes de realmente fazer com que o jovem se posicione de maneira consciente em relação a esse assunto