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1.
Autops. Case Rep ; 6(4): 27-33, Oct.-Dec. 2016. ilus
Article Dans Anglais | LILACS | ID: biblio-905080

Résumé

Histoplasmosis is the most common endemic mycoses among HIV-infected people. Patients with suppressed cell immunity mainly due to HIV are at increased risk of disseminated disease. Dermatological manifestations of immune reconstitution inflammatory syndrome (IRIS) and cutaneous manifestations of histoplasmosis similar to an IRIS event have been previously described. We report the case of a 43-year-old male who presented with cutaneous disseminated histoplasmosis due to Histoplasma capsulatum var. capsulatum 4 months after the onset of the antiretroviral therapy and some improvement in the immune reconstitution. After 2 weeks of amphotericin B and itraconazole therapy, the scheduled treatment involved fluconazole maintenance therapy, which resulted in an improvement of his skin lesions.


Sujets)
Humains , Mâle , Adulte , Histoplasmose/traitement médicamenteux , Syndrome inflammatoire de restauration immunitaire/traitement médicamenteux , Amphotéricine B/usage thérapeutique , Thérapie antirétrovirale hautement active , Fluconazole/usage thérapeutique , Itraconazole/usage thérapeutique , Peau/traumatismes
2.
Article Dans Anglais | IMSEAR | ID: sea-86251

Résumé

In a short span of two and a half decades, HIV/AIDS has emerged as second largest killer disease that has affected mankind. The triple drug antiretroviral therapy (ART) has ensured a reasonably good quality of life to HIV infected individuals. Human immunodeficiency virus (HIV) infection is associated with several opportunistic infections/malignancies that may be life threatening and need quick intervention by health care workers. These emergencies could be related to opportunistic infections that are seen at presentation or that occur as the immune system gets weaker, or may bedue to HIV itself per se. The emergencies could also result from use of antiretroviral drugs like lactic acidosis, pancreatitis, bone marrow suppression and may include the immune reconstitution syndromes. The emergencies due to the opportunistic conditions and HIV per se had been dealt with in detail in the part 1, and this part describes various emergencies that could be encountered due to the administration of the anti retroviral treatment. Some patients may present due to emergencies as a result of co-administration of antiretroviral drugs with drugs used for treatment of some opportunistic infections like ATT etc.


Sujets)
Infections opportunistes liées au SIDA/traitement médicamenteux , Agents antiVIH/effets indésirables , Services des urgences médicales , Infections à VIH/complications , VIH-1 (Virus de l'Immunodéficience Humaine de type 1) , Humains , Syndrome inflammatoire de restauration immunitaire/traitement médicamenteux , Facteurs de risque
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