Résumé
ABSTRACT: Fetuin-A is a potent inhibitor of calcium-phosphate precipitation and of the calcification process, therefore it can also be related with dental calculus. Thus, we aimed to investigate a possible relationship between fetuin-A gene polymorphism and the presence of dental calculus. A possible relationship between serum, saliva and gingival crevicular fluid (GCF) levels of fetuin-A was also investigated. Fetuin-A c.742C > T and c.766C > G polymorphisms were investigated in 103 patients with or without dental calculus. Additionally, serum, saliva and GCF fetuin-A levels of patients were compared according to dental calculus presence. A significant difference was not observed in the distribution of the fetuin-A c.742C > T and c.766C > G polymorphisms between patients with or without dental calculus. Saliva and GCF fetuin-A concentrations of patients with dental calculus were statistically higher than those without dental calculus (P=0.001, P=0.036 respectively). According to our results, fetuin-A c.742C > T and c.766C > G polymorphisms were not associated with presence of dental calculus. However, higher GCF and saliva fetuin-A levels were detected in patients with dental calculus than in patients without dental calculus, which may result from an adaptive mechanism to inhibit mineral precipitation and eventually calculus formation.
Sujets)
Humains , Mâle , Femelle , Adulte , Jeune adulte , Polymorphisme génétique , Salive/composition chimique , Tartre dentaire/composition chimique , Exsudat gingival/composition chimique , alpha-2-HS-glycoprotéine/analyse , alpha-2-HS-glycoprotéine/génétique , Valeurs de référence , Salive/physiologie , Test ELISA , Tartre dentaire/physiopathologie , Tartre dentaire/génétique , Études cas-témoins , Analyse de variance , Exsudat gingival/physiologie , Statistique non paramétrique , Plaque dentaire/composition chimique , Études d'associations génétiques , Génotype , Adulte d'âge moyenRésumé
El efecto del hábito de fumar en pacientes con patologías gingivoperiodontales, ha sido seriamente estudiada en los últimos años. A pesar de que la placa bacteriana no difiere en el fumador resoecto del no fumador hay, en cambio, efectos perjudiciales en los mecanismos defensores de la encía, cemento radicular, formación de cálculos, etc. Estas evidencias determinan una terapia con algunas diferencias en relación al tratamiento habitual y un riesgo de recidiva de la lesión más pronunciado que en un paciente no fumador