Preparation, characterization, thermal studies, photochemical behaviours and antimicrobial activity of complexes derived from 5-methyl-3-furaldehyde thiosemicarbazone and HG[II] salts of hallo acids

Complexes from of 5-methyl-3-furaldehydethiosemicarbazone [5M3HFTSC] and Hg[II] salts derived from inorganic [HCl] and organic hallo acids [CHCl2COOH or CF3COOH] have been prepared. There chemical structures were characterized using elemental analyses, conductivity spectral measurements, thermogravimetric methods and photochemical behaviours. The thermal studies of such complexes using thermogravimetric analysis [TGA], derivatives thermogravimetry [DrTG] from ambient temperature to 750°C showed three decomposition steps. These studies indicated that the thermal decompositions are not simples. The photolysis of the studied compounds has been carried out in the presence of H2O2. It was found that, the photolysis was enhanced in the presence of H2O2 due to the generation of .OH radicals which are very strong oxidizing agent. Biological activity of theses compounds was tested and screened for their in-vitro antibacterial and antifungal activity. The mixed ligand complexes generally are more active than the binary and free thiosemicarbazne ligand

Síntese de tiossemicarbazonas derivadas de 2-(fenoxi)acetaldeídos com potencial atividade antiviral / Synthesis of some thiosemicarbazones of 2-(phenoxy)acetaldehydes as potential antiviral agents

As tiossemicarbazonas constituem classe de compostos que têm apresentado amplo espectro de ação, englobando atividades antibeoplásica, antiinflamatória, tuberculostática e antiviral, inclusive anti-HIV. Diante da potencial atividade antiviral das tiossemicarbazonas, planejamos sintetizar nova série de compostos a partir da tiossemicarbazida e fenoxiacetaldeídos diversamente substituídos. Os produtos obtidos tiveram sua estrutura química comprovada por meio de métodos espectroscópicos no infravermelho e ressonância magnética nuclear de hidrogênio e microanálise. Cinco compostos foram testados visando encontrar possível atividade antiviral. Nos ensaios utilizaram-se culturas de células contínuas VERO e L929 infectadas pelo vírus herpes humano tipo I, da vaccínia, poliomielítico tipo I e da estomatite vesiculosa...

Síntese e atividade biológica de novas tiossemicarbazonas / Synthesis and biological activity of new thiosemicarbazones

Este trabalho descreve a síntese e avaliaçäo estrutural de nove tiossemicarbazonas, obtidas pela condensaçäo de ariltioacetaldeídos e artiopropanonas substituídas com cloridrato de tiossemicarbazida. Estes novos compostos foram testados in vitro pelo fitoteste Lepidium sativum. Todos eles apresentaram atividade inibidora do crescimento celular (pI50) superior àquela de 5-fluoruacila, composto anticancerígeno, utilizado como referência.

Synthesis of thiosemicarbazones, thiazolines and thiazolidinones derived from Theophylline as potential anticancer agents

A series of novel thiosemicarbazone derivatives of theophylline was Synthesized, then cyclized to the corresponding thiazoline and thiazolidinone derivatives with the aim of obtaining new anticancer agents with diminished toxicity

Synthesis and reaction of 5- [6,6-dimethyl-1-4-oxo4, 5,6,7-teteahydroindol-2-yl] -1,3-diarylpyrazolines

A number of 3-[6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindol-2-yl]-1- aryl-2-propen-1-ones II-V have been prepared and transformed into the corresponding arylhydrazones VI-XI. The latter compounds were cyclized to the pyrazolines XII-XX, which were oxidized the corresponding pyrazoles XXI-XXIV. The spectral properties of the prepared compounds were discussed