Résumé
Background: INR is used to monitor the treatment with vitamin K antagonists. A strategy to reduce waiting times for sampling is to measure INR in a capillary sample using a portable point of care (POC) type coagulometer. Aim: To evaluate the correlation of CoaguChek Pro II™, Xprecia™ and microINR™ with venous INR measured at the clinical laboratory and their ease of use. Materials and Methods: Patients provided capillary and venous blood samples for parallel tests comparing Xprecia™ Stride with CoaguChek Pro II™ and with venous INR, microINR™ with CoaguChek Pro IITM and with venous INR. The devices' ease of use was assessed surveying the sampling staff. Results: The three tested devices had good correlation coefficients with venous INR: CoaguChek Pro IITM 0.953 and 0.962; Xprecia™ of 0.912 and microINR™ of 0.932. The correlation coefficient of Xprecia™ with CoaguChek Pro IITM was 0.937 and microINR™ with CoaguChek Pro IITM was 0.976. Conclusions: CoaguChek Pro IITM, Xprecia™ and microINR™ results had a good correlation coefficient with INR measured at the laboratory. Our results indicate that, in the hands of trained users, POC-type coagulometers are reliable and acceptable for routine use in anticoagulant treatment control.
Sujets)
Humains , Mâle , Femelle , Adulte d'âge moyen , Sujet âgé , Systèmes automatisés lit malade/normes , Rapport international normalisé/instrumentation , Normes de référence , Vaisseaux capillaires , Thromboplastine/usage thérapeutique , Chili , Reproductibilité des résultats , Surveillance des médicaments/instrumentation , Surveillance des médicaments/normes , Rapport international normalisé/normes , Anticoagulants/usage thérapeutiqueRésumé
O objetivo final do presente trabalho é esclarecer dúvidas ainda exixtentes no tratamento das hemorragias digestivas agudas. A real eficiência das drogas anti-hemorrágicas e o risco de propciar sangramentos que certos medicamentos encerram sao discutidos, detalhando-se as bases fisiopatológicas e o modo de açao de cada um deles, facultando aos leitores a decisao final.