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Yonsei Medical Journal ; : 37-44, 1998.
Article Dans Anglais | WPRIM | ID: wpr-66288

Résumé

For the purpose of investigating the pattern of E-cadherin (E-CD) expression in thymomas, 72 cases were immunostained using monoclonal antibody (HECD-1) and microwave-enhanced immunohistochemical method on formalin-fixed, paraffin-embedded tissue sections. The thymomas were classified according to modified Muller-Hermelink classification. The spindle-shaped, medullary type tumor epithelial cells in medullary (3 cases) and composite type (20 cases) thymomas rarely expressed E-CD except in focal areas showing microcystic change observed in 8 cases. Meanwhile, the cohesive epithelioid tumor cells in every case of well-differentiated thymic carcinomas (WDTC) (29 cases) expressed E-CD. The epithelial cells in cortical type (13 cases) expressed stronger E-CD compared with those of organoid type (7 cases). In cases of WDTC admixed with cortical type, we observed increasing expression of E-CD as the tumor epithelium forms cohesive sheets. We could not find any loss of E-CD expression in invasive foci of the 11 cases of high-staged WDTC examined. Since the results of our study show a strong correlation between E-CD expression and epithelioid morphology of the tumor, E-CD seems to play a major role as a morpho-regulatory factor rather than as a suppressor of invasion in organotypic thymomas.


Sujets)
Adulte , Sujet âgé , Femelle , Humains , Mâle , Adolescent , Cadhérines/immunologie , Cadhérines/analyse , Immunohistochimie , Adulte d'âge moyen , Stadification tumorale , Thymome/anatomopathologie , Thymome/classification , Thymome/composition chimique , Tumeurs du thymus/anatomopathologie , Tumeurs du thymus/classification , Tumeurs du thymus/composition chimique
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