Tratamiento de tumores de células gigantes / Traitement des tumeurs à cellules géantes / Treatment of Giant Cell Tumors

Introducción: el tumor de células gigantes se presenta en adultos jóvenes, y su capacidad metastásica obliga a realizar un tratamiento quirúrgico, aunque su tasa de recurrencias hace que no haya consenso respecto a la conducta terapéutica. Método: 23 pacientes fueron intervenidos en el periodo de 1996 a 2012 en el hospital universitario Miguel Servet, a los que se les realizó un seguimiento medio de 8,9 años. Resultados: el resultado funcional fue satisfactorio en todos los casos, pues todos los pacientes pudieron reanudar su actividad física habitual. Se detectaron 6 pacientes con recurrencias que fueron tratadas quirúrgicamente; estos pacientes también tuvieron una recuperación total. Un paciente falleció a causa de metástasis pulmonares. Conclusiones: el tratamiento quirúrgico es el más indicado en tumores de células gigantes, se lograron buenos resultados tanto en el tratamiento del tumor primario como de las recidivas(AU)

Introduction: giant cell tumor occurs in young adults, and their metastatic capacity requires a surgical treatment, although the recurrence rate makes no consensus on the therapeutic approach. Method: twenty-three patients were operated from 1996 to 2012 at Miguel Servet University Hospital; they underwent an 8.9 year-mean follow up. Results: the functional result was satisfactory in all cases, for all patients were able to return their usual physical activity. Six patients with recurrences were surgically treated; these patients also had a full recovery. One patient died of pulmonary metastases. Conclusions: surgical treatment is the most suitable approach in giant cell tumors, good results were achieved both in the treatment of primary tumor as well as of recurrence(AU)

Introduction: La tumeur à cellules géantes se rencontre chez des jeunes adultes, et sa capacité de métastase impose un traitement chirurgical, quoique son taux de récurrence empêche qu'il n'y ait pas de consensus sur la conduite thérapeutique à suivre. Méthodes: Dans la période 1996-2012, vingt-trois patients ont été traités chirurgicalement à l'hôpital universitaire Miguel Servet, et ils ont été suivis pendant une période moyenne de 8,9 ans. Résultats: Il y a eu des résultats satisfaisants en ce qui concerne la fonction, parce que tous les patients ont pu reprendre leurs activités quotidiennes. Dans quelques cas (6 patients), on a détecté des récurrences qui ont été traitées chirurgicalement. La récupération de ces patients a été totale, mais un patient est décédé à cause d'une métastase pulmonaire. Conclusions: Le traitement chirurgical est la conduite la plus appropriée dans les cas de tumeur à cellules géantes. On a obtenu de bons résultats dans le traitement de la tumeur primaire et des récidives(AU)

Primary giant cell malignant fibrous histiocytoma of the kidney with staghorn calculi.

Malignant fibrous histiocytomas (MFH) as primary renal tumours are rare, with less than 50 cases described in the literature. We report a case of primary renal MFH of giant cell type in a 56-year-old man, who presented with bilateral dull flank pain, intermittent gross haematuria and body weight loss (6 kg in 3 months). Intravenous urography, computerized tomography (CT) and magnetic resonance image (MRI) showed right ureteral stones with mild hydronephrosis, and a solid mass at the lower pole of the left kidney associated with staghorn calculi, as well as tumour thrombi in the left renal vein and inferior vena cava. Left radical nephrectomy and evacuation of tumour thrombi from the left renal vein and inferior vena cava were performed. Histopathologic examination revealed malignant fibrous histiocytoma (MFH) of giant cell type. To the best of our knowledge, this is the first report of primary renal MFH associated with staghorn calculi.

Tumor de células gigantes em pacientes com imaturidade esquelélica / Giant-cell tumor in patient with skeletal immaturity

Os autores estudam 252 casos de tumor de células gigantes (TGC) atendidos no Departamento de Ortopedia da Faculdade de Medicina da Universidade de Sao Paulo no período de 1944 a 1993; encontram apenas dois casos (0,8 por cento) de localizaçäo estritamente e metafisária, sendo que estes pacientes ainda näo haviam completado sua maturidade esquelética. Apresentam os casos e discutem o quadro clínico, procedimentos realizados e resultados cirúrgicos. Näo houve recidiva do tumor, com bom resultado funcional na evoluçäo de 34 e seis meses, respectivamente. Concluem que o TGC metafisário é entidade rara em pacientes que ainda apresentam imaturidade do sistema músculo-esquelético.

Giant-cell tumour of dorsal vertebra presenting as a mediastinal mass.

A case of large giant-cell tumour arising from the 6th dorsal vertebra and presenting as a posterior mediastinal mass is reported. To our knowledge, such a large mediastinal mass due to a giant-cell tumour has not been reported.

Giant cell tumor of the scapula associated with secondary aneurysmal bone cyst

Giant cell tumors are distinctive neoplasms characterized by a profusion of multinucleate giant cells scattered throughout a stroma of mononuclear cells. Most giant cell tumors are found at the epiphyses of long bones, especially around the knee joint. Flat bone involvement is rare. However, a case of giant cell tumor with secondary aneurysmal bone cyst was encountered at the scapula of a 25-year-old man. Since the occurrence of a giant cell tumor with secondary aneurysmal bone cyst on flat bones (i.e., the scapula) is extremely rare, the above-mentioned case is worthy of reporting.

Tumor de células gigantes: um problema difícil, reporte de um caso / Giant cell tumor: a difficult problem, report of a case

Se reporta sobre un caso de tumor de células gigantes de tibia distal que si bien se pudo tratar satisfactoriamente desde el punto de vista ortopédico se complicó con metástasis pulmonares demostradas en biopsia