Male Genitourinary Tumors : 14 Years Experience in Garhwal Region of India.

Genitourinary tumors may show varied clinical presentation and frequency in different regions of the world. The present study was therefore conducted to analyze the frequency, clinical presentation and the histopathological types of the various male genitourinary tumors diagnosed over a period of 14 years in a major teaching institute of north Himalayan region of India. Material and Methods: Retrospective study was undertaken in the Pathology department of the Institute which included all the cases of male genitourinary tumors which were diagnosed on histopathology from the time period between 1 Jan 1997 till 31st Dec. 2010. Results: The study showed that prostate was the most common site for male genitourinary tumors with prostatic adenocarcinoma as the most common histopathological type of tumor. Testicular Non- Hodgkin’s lymphoma constituted about 8% of total tumors in testes which mostly presented in elderly age group. Renal cell carcinoma (66.2%) was the most common tumor in kidney with much lower frequency of Wilm’s tumor (16.9%). Occasional rare tumors such as hemangioma of urinary bladder and schwannoma of penis were also seen over 14 years. Conclusion: The study concludes clinically patients were associated with more severe symptoms as they presented late to the hospital from the remote areas of this Himalayan region leading to late detection of tumors. Prostatic adenocarcinoma was the most common tumor while renal cell carcinoma was most common tumor in kidney. The present study provides valuable information to clinicians and pathologists regarding frequency, clinical presentation and histopathological types of male genitourinary tumors in this region which can be further used to formulate strategies for better management of these tumors.

Tumor adenomatoide urológico: presentación clínico-patológica de 14 casos / Urologic adenomatoid tumor: clinico pathological presentation of 14 cases

El Tumor Adenomatoide es la neoplasia paratesticular más frecuente y localizada principalmente en el epidídimo. Material y método: Se presenta una serie clínico-patológica de 14 tumores adenomatoides urológicos diagnosticados entre 1975-2011. Resultados: La edad media de presentación fue de 46 años (rango 32-67 años). La mayoría de los casos se presentó como un nódulo firme indoloro en el epidídimo. No hubo casos de localización intratesticular. Se realizó tumorectomía en 13 casos y además orquiectomía en uno. Los tumores midieron una media de 1.9 cm (rango 0.3-5 cm) y macroscópicamente fueron sólidos, blanquecinos y bien delimitados. A la histología estaban formados por estructuras adenomatoides irregulares rodeadas por tejido fibroso. La inmunotinción para Queratina y Calretinina fueron positivas, lo que apoya el origen mesotelial del tumor. El curso clínico fue benigno en todos los casos, sin presentar recurrencias. Conclusión: Corresponde a una neoplasia benigna urogenital rara de origen mesotelial y que compromete con frecuencia el epidídimo. Se presentaron en hombres de edad media y que en la mayoría fueron tratados con tumorectomía, mostrando un curso clínico benigno...

Adenomatoid Tumor is the most frequent paratesticular neoplasia and it is located mainly in the epididymis. Material and methods: A series of 14 cases of Urological Adenomatoid Tumor diagnosed between 1975 - 2011 is presented. Results: Average age at presentation was 46 years (range 32-67 years). The majority of the cases were presented as a painless and firm nodule in the epididymis. No cases involving the testicular parenchyma were seen. The tumors measured an average of 1.9 cm (range 0.3 - 5 cm) and grossly all cases were solid, whitish and fair/y well demarcated. The histology revealed adenomatoid structures surrounded by fibrous tissue. The immunostains were positive for keratin and calretinin which support‘ the mesothelialial origin of the tumor. All cases showed a benign clinical course and no relapses were found. Conclusion: Correspond to a rare benign urogenital/neoplasia that frequently involves the epidermis. They were presented in middle age men and in the majority of the cases were treated by lumpectomy, showing a bening clinical course...

Valoración clínica de las lesiones bucales y genitales en pacientes portadores de papiloma virus humano (H.P.V.) / Clinical assessment of oral and genital lesions in human papillomavirus patients (H.P.V.)

Se describen los hallazgos clínicos e histológicos de la mucosa bucal en una muestra de 85 personas de ambos sexos portadores de condilomtosis genital que concurrieron a la Clínica Ginecológica B de Cuello y Vulva del Prof. Dr. J. Polto del Hospital Pereira Rossell entre 1991 y 1995. En un total de 56 pacientes (65 por ciento) con lesiones en ambas topografías, se encontraron 59 lesiones bucales compatibles con infeción por H.P.V. con un total de 40 (67 por ciento) con biopsia positiva. De manera que la presencia de condilomatosis genital debe alertar al clínico de investigar la presencia de lesiones similares en la cavidad bucal

Descriptive epidemiology of the cancers of male genital organs in greater Bombay.

For different reasons cancers of the Prostate, Testis and Penis are important diseases for men. The incidence for prostate and testicular cancers are more commonly seen in developed countries, while penile cancer occurs more frequently in the developing countries. In Mumbai the incidence of prostatic and testicular cancers is low whereas penile cancer is high when compared with international reports. In Mumbai. The incidence of prostatic cancer increases only after the age of 50. The age specific incidence rates for testicular cancers are bimodal whereas the incidence of Penile cancer increases exponentially with age, after the age 30. In Mumbai. The incidence of Prostate cancer was six times higher in the Parsis as compared to other communities. The incidence of cancer of the testis is lowest in Hindus and cancer of penis is not seen in Muslims. The incidence of prostate cancer was highest among Gujrathis and there was an absence of penile cancer in Urdu speaking men. In Bombay the incidence of cancers of the prostate, testis and penis seem to be associated with marital status. The association between incidence and education level of the patients was only found in men having cancer of the testis. There seems to be an increase in age adjusted incidence rates for cancers of the prostate and testis over time period of 30 years, whereas penile cancer incidence was decreasing over the same period.

Cancer profile in eastern Rajasthan.

A study to determine the pattern of various malignancies in Eastern Rajasthan was conducted for the year 1990 by Cancer Registry, S.M.S. Medical College, Jaipur. This is the first study of its kind from this region where an effort has been made to put the cancer profile in East Rajasthan in perspective. A total of 2509 histologically proven cancer cases were recorded from the various government and private hospitals in this region. There were 1443 males and 1066 females. Maximum number of cases were seen in the 6th and 5th decade. Genital tract cancer (21%) formed the largest overall group of cancers. When combined with the urinary system (7.6%)--the uro-genital tract cancers (28.7%) formed almost one-third of all cancers in this region. Cancer of the prostate (11.40%) and urinary bladder (9.1%) in males recorded the highest incidence in the country. Cancer of the female breast (19.4%) surpassed cancer cervix (18.2%). The frequency of penile, testicular, bone, skin, anorectal cancers and lymphoma was on the higher side. Whereas the incidence of stomach, oesophagus and lung cancer was on the lower side. An urgent need is felt to study the various aetiological factors responsible for these significant variations in Eastern Rajasthan.

Papilomatosis genital: enfoque actual / Genital papilomatosis: present approach

Los papovavirus son un grupo de virus qua ha adquirido cada vez mayor importancia médica. Esta familia contiene dos géneros: papillomavirus y polyomavirus. El género papillomavirus es responsable de diversas variedades clínicas de verrugas del hombre, entre ellas las verrugas genitales. A la verruga genital se le conoce también como condiloma acuminado, el cual se ha relacionado a cáncer del cuello uterino y útero o cáncer del pene. Estas verrugas son de color blanco rosado, húmedas y blandas. Se pueden formar acúmulos sobre los genitales externos, región perianal, o en vagina, cuello uterino, mucosa anal y de uretra. Debido a su localización llegan a presentar maceración y mal olor. El diagnóstico se basa en la observación clínica y estudio citológico de muestras. Hoy día también se puede llevar a cabo el diagnóstico mediante el análisis por restricción enzimática y técnica de hibridación del ADN viral. Hasta la fecha no se ha logrado aislar al virus en cultivos celulares. El tratamiento se basa en el uso de agentes químicos como la podofilina o el ácido tricloro acético y métodos físicos-mecánicos como la crioterapia, electrocirugía o extirpación quirúrgica. El rayo láser ofrece ciertas perspectivas en la resolución de esta patología en el momento actual