Muir Torre syndrome: a case report.

Muir Torre Syndrome (MTS) is a rare syndrome complex of association of multiple sebaceous skin tumors with visceral malignancies. Till date a total of 205 cases have been reported in the world literature and to the best of our knowledge this is the first case report from the Indian subcontinent. Multiple, synchronous and metachronous, tiny sebaceous lesions is a hallmark of MTS along with multiple primary carcinomas at different sites, the commonest being gastro-intestinal tract cancers. The visceral cancers occur at a relatively young age. They are low-grade, non-aggressive and have a good prognosis. Awareness of this rare entity is essential. A case report of a 55-year-old male presenting with multiple sebaceous skin tumors, colonic cancer and positive family history in younger brother is presented.

Sebaceous nevus syndrome as the underlying cause of intractable seizures in a one-month-old infant.

A one-month-old male infant with generalized seizures since 2 days old was evaluated at the Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. His seizures were initially characterized as focal movement of the right upper and lower limbs followed by generalized tonic. Initially, phenobarbital was administered but failed to control his seizures. Physical examination revealed generalized mild hypotonia with a hyperpigmented brownish patch affecting the left side of his face. The initial diagnosis was sebaceous nevus syndrome which is one of the neurocutaneous syndromes. The diagnosis was confirmed by skin biopsy of the affected lesion. The literature was reviewed and discussed. The authors emphasized the importance of thorough physical examination including evaluation of specific skin lesion which would be a leading clue in making the diagnosis of symptomatic epilepsy in infants.