Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 2 de 2
Filtre
Ajouter des filtres








Gamme d'année
1.
Int. braz. j. urol ; 45(6): 1260-1265, Nov.-Dec. 2019. tab, graf
Article Dans Anglais | LILACS | ID: biblio-1056329

Résumé

ABSTRACT Testicle tumors are a rare entity among men population, accounting for only 1-1.5% of all cancers among men. The stromal tumors of the sexual cord correspond just 4% of all testicular cancers. Only 10% of them are malignant. The major representative of the sex cord-stromal tumors is the Leydig cell tumor, corresponding to 75 to 80% of the total. It has bimodal age incidence, involving children and adults between 30 and 60 years. We report the caso of a 91-year-old man with malignant Leydig cell tumor, presenting increase of the volume of scrotum, local pain and hyperemia. The are few cases in the literature, only 1 with pacient above 85 years old.


Sujets)
Humains , Mâle , Tumeurs du testicule/anatomopathologie , Tumeur à cellules de Leydig/anatomopathologie , Scrotum/anatomopathologie , Tumeurs du testicule/immunologie , Maladies rares , Tumeur à cellules de Leydig/immunologie , Anticorps antitumoraux
2.
IJRM-Iranian Journal of Reproductive Medicine. 2013; 11 (11): 919-924
Dans Anglais | IMEMR | ID: emr-148470

Résumé

It has been suggested that malfunction of immune system may causes testicular cancer. Recently, our understanding of innate immune system has been expanded, by discovery of "Toll-Like Receptors" [TLRs]. Some studies have shown that polymorphisms of TLR2 and 4 may affect on the risk of cancer. Also, the role of TLRs 3 and 9 have been shown in apoptosis and metastasis of cancer cells in animal models. Little information is available about the influence of innate immunity on testicular malignancy. Therefore, expression of TLRs 2, 3, 4 and 9 as main components of innate immunity has been investigated in this study. In this case control study, TLRs gene expression was examined by RT-PCR in normal testis and testicular cancer tissues. Real time quantitative PCR [Q-PCR] analysis was used to compare the relative expression of TLRs between the samples. mRNAs of TLR 2, 3, 4 and 9 were expressed in all normal and cancer samples. Q-PCR reveals that cancer samples had stronger expression of these genes compared with normal ones. It seems that the different TLRs expression in testicular cancer cells may contribute to extensive signaling pathways involved in carcinogenesis


Sujets)
Humains , Mâle , Tumeurs du testicule/immunologie , Immunité innée , Récepteurs de type Toll , Facteur de transcription NF-kappa B , Études cas-témoins
SÉLECTION CITATIONS
Détails de la recherche