Résumé
AIMS: This study was conducted to compare the duodenal and jejunal disaccharidase levels in the same individual with duodenal ulcer or non ulcer dyspepsia. METHODS: Thirty seven patients (duodenal ulcer--11, non-ulcer dyspepsia--26) were included in the study. Endoscopic biopsy samples were obtained from jejunum and duodenum using pediatric colonofibroscope. RESULTS: Levels of jejunal disaccharidases were significantly higher than the duodenal disaccharidases. CONCLUSIONS: An estimate of jejunal disaccharidases can be had by multiplication of duodenal disaccharidased by a factor 1.48 for lactase, 1.50 for sucrase and 1.56 for maltase.
Sujets)
Disaccharidases/analyse , Ulcère duodénal/métabolisme , Duodénum/métabolisme , Dyspepsie/métabolisme , Endoscopie gastrointestinale , Femelle , Humains , Jéjunum/métabolisme , Mâle , Adulte d'âge moyenRésumé
O ferro proteinsuccinilato é um novo preparado de ferro adequado à administraçäo oral. Esta molécula näo libera íons de ferro no pH gástrico (o que melhora a tolerabilidade do produto), mas somente a nível duodenal. A absorçäo do ferro do ferro proteinsuccinilato foi relatada por outros autores que notaram um aumento dos níveis séricos de ferro após a administraçäo oral do composto. Com o mesmo método estudamos a absorçä do ferro do ferro proteinsuccinilato antes e após um período de tratamento de seis semanas com ranitidina, um antagonista dos receptores H2 da histamina (300mgh/dia), em indivíduos com úlcera duodenal. O tratamento con ranitidina näo modificou a absorçäo do ferro do ferro proteinsuccinilato
Sujets)
Humains , Mâle , Adulte d'âge moyen , Composés organométalliques/pharmacocinétique , Absorption intestinale , Fer/pharmacocinétique , Succinates/pharmacocinétique , Ulcère duodénal/métabolisme , Duodénum/métabolisme , Concentration en ions d'hydrogène , Fer/sang , Ranitidine/usage thérapeutiqueRésumé
Basal acid output (BAO) and maximal acid output (MAO) were studied in a group of duodenal ulcer patients needing surgical treatment and in a group of healthy control subjects. The MAO levels in both the patients and the controls were lower than those reported from Europe, North America or Hongkong but were similar to those from India. The BAO levels were similar to those observed by workers in other countries. The MAO levels of the duodenal ulcer patients were much higher than those of the control subjects and there was hardly any overlap between the two groups. The ulcer patients had levels of greater than 15.0 mmol/hour. Whether duodenal ulcer patients from Bangladesh with MAO values of over 15.0 mmol/hour will always need surgery remains to be studied.