Résumé
Background: Glycine inhibits the formation of advanced glycation end products that may cause central and peripheral neuronal damage, affecting also the auditory nerve. Aim: To evaluate the effect of glycine on auditory nerve conduction and hearing level among patients with type 2 diabetes mellitus and auditory neuropathy. Material and Methods: Twenty grams of oral glycine per day were administered during 6 months to 28 type 2 diabetic patients aged 58 ± 6 years, with auditory pathway neuropathy. Hearing tests and evoked otoacustic potentials were performed regularly. Fifteen diabetic patients aged 49 ± 8 years, without auditory nerve neuropathy did not receive glycine and were followed as a control group. Results: Among patients receiving glycine, a significant improvement in left ear audiometry at 125, 250 and 500 Hz and right ear audiometry at 500 Hz, was observed. Waves I, III and V (p= 0.02) of evoked otoacustic potentials improved significantly in the left ear and wave I in the right ear. Among controls, waves V and III of evoked otoacoustic potentials had a significant impairment in the left ear. Conclusions: There was an improvement in auditory evoked potentials in patients receiving glycine and an impairment in untreated control patients.
Sujets)
Femelle , Humains , Mâle , Adulte d'âge moyen , Voies auditives/effets des médicaments et des substances chimiques , /complications , Neuropathies diabétiques/thérapie , Potentiels évoqués auditifs/effets des médicaments et des substances chimiques , Agents glycinergiques/usage thérapeutique , Glycine/usage thérapeutique , Audiométrie , Voies auditives/anatomopathologie , Voies auditives/physiopathologie , Neuropathies diabétiques/physiopathologieRésumé
Os autores apresentam 12 casos de tumores malignos de conduto auditivo e osso temporal tratados no Serviço de Cirurgia de Cabeça e Pescoço do Hospital Heliópolis - SP sendo que 10 pacientes foram submetidos a ressecçäo subtotal do osso temporal, um paciente foi submetido a ressecçäo parcial do osso temporal e um paciente foi encaminhado a radioterapia por estado geral incompatível com tratamento cirúrgico. Concluem pela agressividade destas lesöes, pois oito destes pacientes haviam sido tratados previamente com procedimentos cirúrgicos econômicos e, portanto, pela necessidade de padronizaçäo da terapêutica através de ressecçäo parcial ou subtotal do osso temporal com cobertura dos ossos expostos e leito cirúrgico com retalhos regionais ou a distância e radioterapia pós-operatória