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Background: Diabetes is accompanied by a distinct decreased in subject抯 quality of life (QOL) and it shows to elevated disability-adjusted life years than most diseases. Depression shows the degrade QOL and is associated with wretched treatment outcomes and lesser the glycaemic control in diabetes. Objective of this study is to study the association between Quality of Life (QoL) and depression among type2 diabetes mellitus in Andhra Pradesh. Methodology: The present study is a case control study. There were 300 participants including 150 type2 diabetes mellitus patients, & 150 healthy individuals (age and gender matched) were also selected as a control to meet the purpose of the study. Subjects age range was set between 35-65 years. Beck depression inventory (BDI-II) and WHO quality of life scale (QOL BREF) were used for data collection, SPSS-26(v). Results: The study findings showed that significant but negative relation between depression scores and quality of life. 65% have Poor Quality of life & 57% have high depression in Diabetes Patients. 54% have good Quality of life & 78% have Mild Depression in Healthy Individuals. Conclusion: It is concluded that association between depression and sub-scales of quality of life indicating that high depression scores may lead to lower physical and psychological health impacting social relationship and environmental health.
RESUMO
Objective: To evaluate the acute toxicity effects of earthworm powder (EWP) obtained from Eudrillus euginae on wistar male rats. Methods: The animals are treated orally with EWP at the doses of 100 mg/kg, 200 mg/kg and 300 mg/kg bodyweight daily for 12 days. Results: There was no significant mortality and changes in body weight noticed at all the doses tested. No gross significant changes observed in the hematological indices (HB, RBC and WBC), Hepatic, serum markers (AST, ALT, ALP, and protein) and renal indices (Urea, Uric acid and Creatinine). The EWP did not show any significant effects in the clinical signs, behavioral changes and examined toxicological endpoints in experimental animals. The histopathological studies provide supports to the safety data of above parameter of EWP dosing. Conclusions: Thus, it can be inferred from the present study that EWP (Eudrillus euginae) is devoid of toxic effects in rats and suggested to utilize the EWP as novel medicine.