[ effect of supervisors and work group on hospital information system acceptance model]

Issues related to organizations and users are among factors influencing successful implementation of information systems. These factors should be taken into account by managers. The purpose of this study was to examine the influence of supervisors and workgroup on Hospital Information System [HIS] acceptance by users in medical hospitals of Tehran [former Iran] University of Medical Sciences. After the literature review, a primary model including seven variables influencing HIS acceptance was proposed. A questionnaire including 121 questions based on the variables was developed, the validity and reliability of which were tested and confirmed by an expert panel and through Chronbach Alpha. The population of the study were 400 HIS users in hospitals selected by stratified random sampling method. To confirm the model and determine the relationship between variables, Structural Equation Modeling [SEM] method was used by applying LISREL Software. The result of Normed Chi Square Index [x[2]/df= 2.49] showed that the model had fitness with the collected data. According to the model, supervisers and workgroup influenced Perceived Ease of Use, Perceived Usefulness, and Satisfaction which affected users Behavioral Intention to use Hospital Information System in these hospitals [P-value= 0.0054]. Considering the goodnesss of fit indices, it is concluded that supervisors and workgroup factors have the potential to influence HIS acceptance. The application of the suggested model could increase the possibility of HIS acceptance in hospitals under the study

Surveying Desferal production increment by inducing mutation in Streptomyces griseoflavus

Desferal or Desferrioxamine B mesylate is an iron chealator drug. This medicine decreases the iron overload in the thalassemia patients who have been blood transfused; the excess of iron is excreted through bile or urine. Novartis is the sole company which produces desferrioxamine B mesylate in the world and our country is importer of such drug. Thus we tried to increase Desferal production by inducing mutation in Streptomyces griseoflavus. This is an applied research carried out at pilot level. The organism is a Gram-positive bacterium that was supplied in lyophilized by Persian Type culture Collection, Iranian Research Organization for Science and Technology [IROST], Tehran, Iran bearing the code no. PTCC1130, which was cultured on Des4 medium. The organism was mutated by UV irradiation hence selective techniques and markers were employed to distinguish marked strains from parent S. griseoflavus. When the mutated organisms were selected according to their characteristics and used to fuse their protoplasts in order to obtain high yield desferrioxamine producing recombinant Streptomyces griseoflavus. The varied parameters were bacterial growth rate and desferal concentration in the culture broth. Our study showed that the rate of desferal production in mutant's strains called C7031 and S7011 and fusants srains called FP10 and FP9 was higher than wiled type Streptomyces griseoflavus. The increment in production of desferrioxamine was found to be 68% in FP9 and 81% in FP10 fusants. The mutation and protoplasts fusion of Streptomyces griseoflavus caused increment in production of desferrioxamine. The infrared spectrum, thin layer chromatogram of desferrioxamine extracted from culture broth was similar to that of standard desferrioxamine [Novartis] from the point of molecular identity

Safety and immunogenecity of human therapeutic morphine vaccine in morphine addicts

Morphine vaccine is a product of morphine-6- succinate synthesis and its conjugation with albumin serum. Each dose contains 0.5 mg Aluminum hydroxide, 8 mg sodium chloride, 1.12 mg di- sodium hydrogen phosphate, 1.1 mg sodium di- hydrogen phosphate and 50 mg morphine-6-succinate albumin serum. Humoral safety is achieved in morphine addicts following three successive doses within 0-30-60-day intervals. Its immunogenecity brings about withdrawal without the risk of abstinence syndrome. This study was conducted to examine the effect morphine vaccine on morphine addicts. Based on the Ethics protocol of Pasteur Institute of Iran, this clinical trial was conducted on 102 male volunteer addicts [mean age 25 years]. Variables included vaccine dosage and concentration on of antibodies. Volunteers were divided into groups of 30 [experimental] and 4 [placebo]. Adjuant was injected to placebo group addicts; the three experimental groups were given 5, 12, 100 and 600 microg within 0-30-60 days interval through injection to deltoid; all subjects referred for follow-up on the 90[th] day. Blood samples and antibody evaluation was obtained from all three groups in months 5, 7, 9, 11 and 12. A positive correlation was observed between antibody production and vaccine dosage as well as frequency of injection. Anti-morphine antibody was detected after the first injection of 100 microg/ml, 600 microg/ml and second injection of 12.5 microg/ml doses. Antibody levels reached the peak by three months and did not decline to the baseline after one year. The vaccine was well tolerated and lacked the reverse and unfavorable effects, characteristic of vaccines and drugs. On day 90, humoral immunity was created in all patients

Mental health in high-tech system

Stress and mental health at the place of work have received great attention by researchers. In spite of technology improvement in high-tech systems, the operators face new problems, which can affect mental health. There is hardly any published research about stress or mental health in such workplaces in developing countries. This paper presents the application of the self-rating scale General Health Questionnaire [GHQ-28] to study mental health of 160 controllers working in a part of Air Traffic Control [ATC] as a high-tech system in Iran. Logistic regression analysis showed that demographic variables did not exhibit a statistically significant effect on scores of the test. In order to compare mental health of these operators with general population, an exposure / non-exposure study was designed. Three age groups [less than 29 years, 30 through 39 y, and more than 40 y] were compared in exposed and non-exposed groups. The results of Fisher's exact test showed that mental distress symptoms were significantly higher in the exposed group. There were significant job effects on somatization, anxiety and depression as well as on the total score of GHQ-28 for the two first age groups [P<.05]. No significant effects of the job were found on social dysfunction symptoms in any age groups. The risk ratio of expressing depression and anxiety symptoms were more than three times greater in these operators than general population