RESUMO
Catalase is the one of the most important antioxidant enzymes that is found abundantly in liver and kidney
The alteration in activity and function this latter enzyme are widely investigated in various types of cancer to understand the cancer mechanism and its treatment
The changes in the catalase activity levels in a variety of cancer cells is as a specific property of tumor tissues due to the reducting catalase activity at mRNA level
In this review, various reports that examined the alterations in catalase activity and resistance to chemotherapy and its complications in the literature are summarized and discussed
Due to the important role of hydrogen peroxide in various stages of cancer process, catalase alters this process by detoxification of hydrogen peroxide
Chemotherapy increase free radicals to destroy the tumor cells, then, catalase activity reduced their impact on cancer cells
On the other hand, it might be concluded that production of drug resistance in chemotherapy is resulted due to increasing catalase activity. Therefor it seems catalase has contradictory influence on the treatment and development of cancer
RESUMO
In this survey, resistance to albendazole was investigated in 15 sheep flocks from different regions of Khozestan province. On each flock, two groups of 15 sheep including control groups [untreated] and Albendazole group [treated with 5 mg/kg of Albendazole] were selected and the investigation was carried out using faecal egg count reduction test[F.E.C.R.T] for 10 days after treatment. Posttreatment faecal culture and necropsy of 4 sheep from control group and 6 sheep from Albendazole group were done to identify species of resistant nematodes. Results of F.E.C.R.T showed that 27% of the flocks were resistant, 53% were suspected to resistancy and the rest were susceptable to albendazole. Faecal culture of necropsied animals showed that resistantce to albendazole was developed in Ostertagia circumcincta and Marshalagia marshali