RESUMO
Background: one of the most important problems in medicine is stress induced peptic ulcer. In spit of its importance, there is no confirming way to prevent it. The aim of this study is test effect of feeding on stress induced peptic ulcer as a preventive way
Method and materials: experiments were performed on 20 wistar male rats weighting 200+/-20 gram that were under standard condition and has free access to water and food. They randomly divided in 4 groups with 5 rats in each group. 1] Fasting group with stress 2] feeding group with stress 3] fasting group without stress 4] feeding group without stress [control]. Cold water [23o] immersion stress for 3.5 hours was used for inducing stress. All rats were killed and their stomachs were revised from point of view numbers and area of ulcers. Data were analyzed by ONE WAY ANOVA
Results: immersion in cold water in this method induced ulcer in stomach, area and number of ulcers in fast with stress group were significantly more than other groups
Conclusion: oral feeding during stress reduces gastric mucosal injury in rats that are under acute stress. It seems that food in stomach prevent stress contractions that induced ulcer due to ischemia