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Feyz-Journal of Kashan University of Medical Sciences. 2010; 13 (4): 271-277
em Persa | IMEMR | ID: emr-197217

RESUMO

Background: Addiction to opioid drugs is considered as a problem throughout the world. Addiction can be studied concerning: social, medical and psychological aspects. The social aspect of addiction is quite important. For example, the negative result of addiction test is a requirement for marriage and job by law. On the other hand, frauds in addiction tests have been reported [such as displacement of urine from bladder, alkalization or acidification of urine and taking of diuretics or oral contraceptives]


Materials and Methods: In the present study, two different chronic morphine administration protocols [tolerance and dependency models] were applied. Estrogen and progesterone were given prior and simultaneously with morphine. After the last injection of morphine, urine samples were taken every 6 h for 24 h. Then morphine was quantitatively detected by High Performance Liquid Chromatography [HPLC]. Data analysis was performed using two-way ANOVA and repeated measures ANOVA test followed by Student-Newman-Keuls test. Conjugated morphine was measured by the subtraction of free part of morphine from the total one in the urine samples


Results: Our results indicated that prior administration of estrogen and progesterone increased the metabolism of morphine 6 and 12 h after the last injection, while no significant change was detected after 18 and 24 h


Conclusion: In summary, it can be concluded that estrogen and progesterone transiently affect the metabolism of morphine. Thus, the effect of the sex hormones on morphine metabolism is not clinically important

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