RESUMO
Background: with recent scientific progresses, the barren couples can become fertile and a part of children are the results of these costly interventions. there have been some concerns and questions about the physical and developmental growth of these children and some wide and continued studies are being done about this subject around the world. Prevalence of multiplicity, LBW, prematurity and congential abnormalities have been shown in these children
Material and Methods: we searched Pubmed and Cochrane databases for relevant articles published from 1991 to 2008. The following keywords were used: Invitro Fertilization [IVF], Intra Cytoplasmic Sperm Injection [ICSI] Assisted Reproductive Technology [ART]
Results: the studies have shown that the majority of neonate of ART methods, have proper prenatal period. the most important confounding factor in healt status of these neonates in prenatal period is multiplicity. ART twins encounter with more prenatal problems and the most important modifying factor is limitting the number of transferred embryos. These children have no difference physically and developmentaly with other children during infancy and childhood and the rate of disease is not higher either
Conclusion: the results of most of the research described suggest that childern conceived using ART, are not at greater risk of physically and developmentaly problem. The risk difference for major congenital malformation, LBW and prematurity are low and probably acceptable for the couples concerned