RESUMO
To determine the protective impact of efficient serum copper concentration on BMD in women and to asses its impression on bone. six hundred healthy women through a national project in Iran, IMOS, were selected via a cluster random sampling and enrolled the study. They were divided to pre menopausal [404/600, 67.7% of total] and post menopausal [190/600, 32%of total] groups. BMD was measured by biphotonic absorptimetry DEXA for hip and lumbar spine. Morning serum copper concentration was determined by atomic absorption spectrometry. Mean age was 40.92 +/- 14.8yr .Mean serum copper concentration 105.85 +/- 40.15microg/dl and mean BMI= 27.13 +/- 4.81 kg/m2.Totaly 2.4% was smoking, 5% had regular physical activities three times a week and 17.5% was copper deficient. Prevalence of Osteoporosis in postmenopausal women was 12.9% in copper deficient persons vs. 11.3% in normal serum copper ones. No significant difference found according to serum copper concentration associated with BMI, age and vitamin D. Spine BMD revealed a significant correlation with serum copper content. [P= 0.001]. This correlation also existed for Total hip [P< 0.05]. Premenopausal women with serum copper level above 105 microg/dl revealed a significant difference in hip BMD compared to whom with less copper concentration. 1.02 +/- 0.13kg/m2 vs. 0.97 +/- 0.13kg/m2 [P = 0.001]. Copper had an independent role on determining hip BMD in pre menopaused women [P= 0.001]. copper has an independent role on bone density in all healthy women. It could have an adjourning factor for bone loss as well as a protective agent for Osteoporosis
RESUMO
A growing body of investigations demonstrated the essence role of zinc on growing and maintaining bone tissue .The idea that zinc could enhance bone content and adjourn or prevent osteoporosis in men, has been experimented as a hypothesis. Six hundred healthy men [age 20-69 yr] through Iranian Multicenter Osteoporosis Study [IMOS] which is a national project running in 5 provinces in Iran for prevention and treatment of osteoporosis was selected via a cluster random sampling and enrolled the study. Bone Mineral Density was measured by biphotonic absorptimetry DEXA for hip and lumbar spine. Zinc morning serum concentration was determined by atomic absorption spectrometry. SPSS 11.5 was used for data analysis. Body Mass Index [BMI] has been calculated by Weight [kg]/Height [meter][2] for each person. The mean age was 40.83 +/- 15.06 yr .Mean BMI was 24.79 +/- 3.94 kg/m2, overlay 27.3% were smoking, 12.5% had regular physical activities three times a week and 12.2% had a history of renal stone. Among them 30.1% had zinc depletion, 56.8% normal range and 13.1% had serum zinc excess. 57.1% of individuals over 40 yr with hip osteoporosis were zinc deficient whereas 22.1% of them with normal BMD had this deficiency [P< 0.001]. It is concluded that zinc has a positive association with BMD in men over 40 yr and zinc deficiency is more common in osteoporotic individuals