RESUMO
This project was aimed to evaluate the efficacy of baclofen in keeping opioid dependents in maintenance treatment and in reduction of their opioid use. It also assessed its superiority over placebo. In this double blind experimental study, 40 patients with the diagnosis of opioid dependence [DSM- IV based criteria] were inserted randomly in two groups following the detoxification phase. In one group, 20 patients took baclofen [60 mg daily in three divided doses] and in the other one, 20 patients took placebo for a total of 12 weeks. The primary measuring factors included retention of patients in maintenance treatment and positive urine analysis. The project's data were analyzed via statistical Mann-Whitney and chi-square tests. The retention of patients in treatment was significantly more in baclofen group than the placebo group. baclofen group patients exhibited less opioid withdrawal and depressive symptoms than the placebo group. There were no significant differences between the two groups in terms of the rate of positive urine analysis, intensity of craving for opioid use, medication side effects, and the average days of opioid and alcohol consumption during treatment. Baclofen is considerably superior to placebo in keeping the patients in treatment and also in reduction of opioid withdrawal and depressive symptoms
Assuntos
Humanos , Transtornos Relacionados ao Uso de Opioides/prevenção & controle , Transtornos Relacionados ao Uso de Opioides , Agonistas GABAérgicos , Comportamento Aditivo/tratamento farmacológico , PlacebosRESUMO
Objectives: This research investigated the prevalence of anxiety disorder among Tehranian population ages 20-64 years in summer and winter 1999-2000
Method: 1070 Tehranian were selected by random cluster sampling method and then they participated in screening anxiety test[Beck Anxiety Inventory].Those, whose scores were higher than the cut of point in anxiety inventory, were psychiatrically interviewed. In case of presence of disorder, its type was determined. The interviewers were blind to the result of patients anxiety test
Findings: The results showed anxiety disorders in about 15% of subjects and also revealed anxiety level among women subjects is two to three times as much as men
Results: The current research presents similarities and differences in comparison with previous studies