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EMHJ-Eastern Mediterranean Health Journal. 2002; 8 (1): 95-104
em Inglês | IMEMR | ID: emr-158044

RESUMO

This study evaluates the effect of DDB on normal and chemically-injured liver. When given to normal rats DDB had no significant effect on liver enzymes, but in chemically-injured rats there was a significant decrease in the elevated levels of liver enzymes. DDB produced a significant increase in reduced glutathione, glutathione peroxidase and glutathione reductase, and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically-injured liver. The histopathology examinations showed a slight improvement with DDB administration. DDB has a beneficial effect on liver enzymes and possesses significant antioxidant properties in normal and chemically-injured liver, and may therefore be clinically useful in treating chronic viral hepatitis B in humans


Assuntos
Animais , Masculino , Adjuvantes Imunológicos , Antioxidantes/farmacologia , Tetracloreto de Carbono , Sistema Enzimático do Citocromo P-450/antagonistas & inibidores , Modelos Animais de Doenças , Glutationa/efeitos dos fármacos , Hepatopatias/tratamento farmacológico , Testes de Função Hepática , Malondialdeído/metabolismo , Ratos
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