Impact of the aqueous extract of eclipta ALBA on maternal aggression in rats

Parturient females display impulsive behavior represented in the form of aggressive bouts when exposed to conspecifics. Prolonged aggression during the postpartum period could affect maternal care. Eclipta alba is traditionally known to induce neuropsychiatric alterations, however its ability to circumvent maternal aggression has not been elucidated. The present study was aimed to investigate the ability of the aqueous extract of Eclipta alba to suppress maternal aggression. In the single dose study, 100, 200 and 500mg/kg body weight of the aqueous extract of Eclipta alba was administered to parturient females 30 minutes prior to maternal aggression testing against intruder males. In the multiple dose study, 100, 200 and 500mg/kg of the extract were administered for 15 and 30 days and maternal aggression was quantified. Administration of the extract for 15 and 30 days in dose schedules of 200 and 500mg/kg body weight significantly suppressed agonistic encounters by the dams and therefore had beneficial anti-aggressive activity

Evaluation of antiaggressive activity of Eclipta alba in experimental animals

The occurrence of aggression for prolonged periods of time could have a hazardous impact on the health and social wellbeing of the individual. Aggression can ensue due to exposure to an intimidating situation. Aggression is prominently seen when a disturbance occurs in the fine balance of neurotransmitters such as 5-hydroxytryptamine, gamma- aminobutyric acid, dopamine and their receptor subtypes. The present study investigated the ability of 100 and 200mg/kg of aqueous extract of Eclipta alba to circumvent aggression. Foot shock induced aggression and water competition test were utilized as models for screening of antiaggressive activity. Eclipta alba significantly minimized dominance [p < 0.05] which is correlated to the level of aggression particularly with 200mg/kg in the water competition test. A tangible behavioral submission was observed with 100 and 200mg/kg and of Eclipta alba in the foot shock induced test