RESUMO
To compare the efficacy of granisetron, metoclopramide and dexamethasone in prevention of post operative nausea and vomiting [PONV] after cataract surgery. Sixty patients scheduled for cataract surgery with age between 45 to 80 years and with ASA class I and II were enrolled in this clinical trial. The patients were randomly allocated to three 20- person groups. The induction of anesthesia in all groups was similar using the same drugs. Granisetron 1 mg IV was administered to patients in the first group and metoclopramide 0.2 mg/kg/IV [Max: 10 mg] was administered to the second group at the end of the surgery. In the third group dexamethasone 0.15 mg/kg/IV [Max: 8 mg] was used before surgery. Patients in all three groups were observed for PONV at defined intervals for 24 hours. Incidence of PONV during first 6 hours after surgery was 5% in granisetron group, 35% in metoclopramide group and 15% in dexamethasone group. Only the difference between granisetron and metoclopramide groups was statistically significant [P= 0.01]. Incidence of late PONV [6-24 h] was 5% in granisetron group, 30% in metoclopramide group and zero in dexamethasone group. This difference was statistically significant [P<0.01]. Granisetron is more effective than metoclopramide in prevention of PONV after cataract surgery. Granisetron and dexamethasone are more effective than metoclopramide in prevention of late PONV after cataract surgery