clinical comparison of prolonged sevoflurance versus isoflurane anesthesia

This study aimed to determine whether prolonged anesthesia with either sevoflurane [S] or isoflurane [I] can produce clinically significant effect on the renal, hepatic and hematologic condition of patients undergoing prolonged orthopedic reconstructive surgeries lasting approximately ten hours. After ethical approval and an informed consent from each patient were obtained before surgery. The patients were classified into two groups according to the anesthetic agent[s], either S group [n = 15] or I group [n = 20]. It was concluded that sevoflurane is at least has comparable effects to isoflurane, and both can be used safely without major hepatorenal or hematological side effects in such type of prolonged surgery