Alpha-1 Antitrypsin and human tumour necrosis factor-alpha in Egyptian patients with fever

Serum alpha-1-antitrypsin and human tumor necrosis factor- alpha [IFN- alpha] were estimated in 20 cases with simple typhoid fever, 20 cases with complicated typhoid fever and 20 normal healthy individual. It was concluded that serum alpha-1-AT and TNF-alpha concentrations showed highly significant changes during febrile period of simple and complicated typhoid fevers and began to decline towards the base control after therapy and convalescence. So, alpha-1-AT and TNF-alpha measurements in typhoid fever were useful detectable parameters in differentiating between simple and complicated groups. Serum alpha-1-AT and TNF-alpha estimations were good markers of early manifestations of recovery and response to treatment in typhoid fever