RESUMO
This study was done to investigate lipid peroxidation by measuring MDA in plasma in experimental uninephrectomy and contra-lateral renal clamping in albino rats. The role of endogenous, antioxidants plasma sodium dismutase [SOD], catalase, vitamin E and vitamin C to antagonise lipid peroxidation was measured. Also, total lipids, blood urea and creatinine was measured to detect lipid peroxidation process and chronicity of tested rats. MDA significantly elevated in tested rats and endogenous antioxidants was lowered as compared with control and sham operated rats except plasma SOD level increased. Also, total lipids, blood urea and creatinine significantly elevated in tested rats after two months. So, it was suggested that whenever patients with renal impairment with hyperlipidaemia develops renal insufficiency, it is better to add antioxidant drugs like vitamin E and vitamin C which may be protective to vessel wall damage in such cases