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Objective: To evaluate side effects of Imatinib by patients of chronic myeloid leukemia and their influence on quality of life. Study Design: Descriptive and analytic study. Place and Duration of Study: The study was carried out at department of oncology CMH Rawalpindi, from Jan 2015 to Dec 2015
Material and Methods: The study was carried out at department of oncology CMH Rawalpindi from Jan 2015 to Dec 2015. Patients who had been using Imatinib orally for at least 6 months participated in the study. Patients under 18 years of age were excluded from the study. A questionnaire was developed to record adverse effects. This questionnaire included demographic details and quality of life issues like effects on their mood, daily life activities, work, walking and relationships
Results: Ninety two patients participated in the study. Mean age of the participants was 42.05 years [range 22 to 68 years], 52% were males. Among the study population eighty-seven percent had suffered from at least one adverse reaction. The most commonly complained adverse events were muscle cramps [67 out of 92, 72.8%]; fatigue [58 out of 92 63.04%], gastro intestinal upset [44 out of 92 47.82%] and skin rashes [30 out of 92 32.60%]. More than half of the patients felt that the adverse effect had a negative influence on their daily quality of life
Conclusion: Adverse drug effects were common among CML patients receiving Imatinib therapy. These adverse drug reactions had negative impact on patients' daily life
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Objective: To investigate phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos. Methods: Fatty acid methyl ester was analyzed by gas chromatography-flame ionization detector. Antioxidant activity was determined using 2,2-diphenyl-picrylhydrazyl radical scavenging assay and total phenolics content by Folin-Ciocalteu procedure. Vero cells viability was evaluated using methyl thiazole tetrazolium and the inactivation of herpes simplex virus type 1 by neutral red uptake assay. p-Hydroxybenzamide isolated by column chromatography was characterized by utilizing nuclear magnetic resonance spectroscopy and electron impact mass spectrometry. Results: The chloroform, ethyl acetate and methanol extracts of Aaptos aaptos produced higher portions of straight-chain saturated fatty acid, while hexane extract mainly consisted of unsaturated fatty acid. The five majors of fatty acid methyl ester were identified as behenic acid, cis-10-heptadecenoic acid and cis-10-pentadecenoic acids, palmitic acid and tricosanoic acid. In addition, among all organic extracts, chloroform extract inactivated herpes simplex virus type 1 while exhibited weak cytotoxic activity against normal Vero cells and also exhibited strong cytotoxic activity on HL-60, MCF-7, K562, CEM-SS and WEHI-3B cells. A phenolic compound, p-hydroxybenzamide was also isolated from the sponge. Conclusions: Aaptos aaptos could be a source to derive the potential antiviral and anticancer agents. However, further studies are needed to determine the mechanism involved in the process.
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To enlist the dominant risk factors predisposing patients to deep venous thrombosis. The prospective study was conducted in surgical and medical departments of Combined Military Hospital, Rawalpindi, and Fauji Foundation, Islamabad, from January 2012 to December 2013. Patients having deep venous thrombosis of lower extremities by duplex scan were enrolled. After taking their detailed personal and biochemical history, frequency of risk factors was noted and graded accordingly. Of the total 120 patients, 71[59%] were males. Overall, left leg was involved in 53[44%], right leg in 34[28%] and both legs in 33[28%]. Of the total, 68[57%] patients were >40 years of age. Immobility was the main cause of deep venous thrombosis in 18[15%], followed by surgical interventions in 10[8%]. Pregnancy and post-partum thrombosis was the major cause in 9[8%] women. Only 6[5%] patients had natural predisposition to deep venous thrombosis. Immobility was an independent and important risk factor for deep venous thrombosis. Thromboprophylaxis is not routinely provided in most health centres in Pakistan, exposing patients to the risk
Assuntos
Humanos , Masculino , Feminino , Fatores de Risco , Estudos Prospectivos , Perna (Membro) , Centros de Atenção TerciáriaRESUMO
Cardiovascular diseases are the most common causes of death worldwide and stress is the reason behind many negative emotions. Surgery is one of the most stressful situations. Coping styles and life expectancy affect people's mental and physical efficacy. The present study aims to determine the effectiveness of training life expectancy and effective coping styles to deal with negative emotions on cardiac surgery patients' mental health at Sari-based Fateme Zahra Hospital in 2013. In this quasi-experimental study, 30 candidates for coronary artery bypass surgery referring to this center was selected using the available sampling method. They were then randomly included into two 15-member groups as experimental and control group. Stress management, anger management, and hopefulness training courses were held individually for 7 sessions. Before and after the intervention, the patients of both groups answered the questionnaires including the Coping Manners Questionnaire [by Lazarus and Folkman], Snyder's Hope Scale, and the General Health Questionnaire-12 [GHQ-12]. Data analysis implied that there is a significant difference between the average general health in the experimental and control groups after training. Investigating the subscales of coping strategies in the experimental and control groups after training showed that there is a significant difference between direct coping, planned problem solving, and positive reappraisal in the two groups. In patients with coronary heart disease, high stress, and negative emotions [anger, anxiety, depression] also as the candidates of coronary artery bypass surgery, training raised life expectancy level and the practical methods for coping with life can be great help to their mental health condition
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Background: Brain contusion surgeries versus conservative treatment are considered to be the typical decisions faced by doctors, resolved usually based on the experience of respective departments. Till date there are no standard guidelines regarding conservative versus surgical management
Objectives: To determine the outcome of the surgical and medical management in posttraumatic brain contusion patients
Methods: The study was conducted on patients having small and large brain contusions admitted in the department were selected through custom Proforma. The 41 patients [31 males 10 females] included corresponded to no specific exclusion criteria. The patients who improved by Glasgow coma score, neurologically or resolution was confirmed by Computed tomography scan brain were categorized under conservative management. While the patients, who deteriorated by Glasgow coma score, neurologically, bradycardia or showed expansion in the size of contusion with mass effect underwent standard decompressive craniotomy or cranectomy and evacuation of contusions along with duroplasty. Complications and improvement of the patients were determined at follow up and monitored by the help of interval brain CT scan during their stay in the department subsequently followed by cranioplasties
Results: There was a male predilection with male to female ratio of 3.1:1. The age group more frequently affected was 20-40 years and the most causative agent was road trauma accident. Complications were found among two patients as intractable seizures, brain abscess formation, hydrocephalus and post operative jaundice in one patient each. Wound infections in four patients. Overall outcome was good in conservative and surgical intervention patients of brain contusions. The total mortality was four patients, two in each group of patients
Conclusion: Therefore we recommend that nonsurgical and surgical management has comparable results, but surgical decompressive craniotomy is the mainstay of treatment based on the essential monitoring tools as repeated interval scanning and neurological evaluation considering the timing of surgery, volume and size of hematoma, conscious status, bradycardia and hypertension
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To evaluate the effect of domestic boiling practice on the contents of water soluble vitamins of loose milk and quantitative comparison of these vitamins in Ultra High Temperature [UHT] treated packaged milk with that of boiled loose milk. Loose milk samples were collected from various localities of Karachi city [Pakistan]. These samples were boiled in simulated household conditions for 5, 10 and 15 minutes. Ultra High Temperature [UHT] treated packaged milk samples of various brands were obtained from the local market. The aliquots were analyzed for water-soluble vitamins using High Performance Liquid Chromatography [HPLC] technique. The mean values and standard deviations for data were computed and compared as well as level of variations were also determined. Conventional boiling caused destruction of water soluble vitamins in milk i.e. vitamin B1 content in fresh milk decreased from 0.037 mg/100g to 0.027 mg/100g after 15 min boiling, whereas vitamin B2 from 0.115 to 0.084 mg/100g, vitamin B3 0.062 to 0.044 mg/100g, vitamin B6 0.025 to 0.019 mg/100g and folic acid 3.38 to 2.40 microgram/100g. This accounted for a post-boiling decrease of about 27, 27, 29, 24 and 36% in vitamins B1, B2, B3, B6 and folic acid respectively. The values for vitamins B1, B2, B3, B6 and folic acid determined in boiled milk were significantly lower than UHT treated packaged milk samples by 25.9, 75.0, 54.5, 63.16 and 38.1% respectively. Conventional boiling caused drastic reduction in vitamin levels of loose milk samples. In comparison to this, UHT milk retained high levels of water soluble B-vitamins. Thus it could be envisaged that UHT treated milk provides better water soluble vitamins' nourishment than conventionally boiled milk