role of renin blockers in the prevention of diabetes

To evaluate the role of renin blockers angiotensin converting enzymes inhibitors [ACEI] or angiotensin receptor blockers [ARB] in the prevention of diabetes. We did a meta-analysis using the Cochrane group methodology of all available randomized controlled trials [RCTs] that evaluated the role of renin blockers in which outcomes of new-onset diabetes was reported. This meta-analysis was conducted between April 2005-April 2006 at King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia. Thirteen trials including 91,388 individuals met the inclusion criteria. There was a statistically significant reduction in the incidence of new-onset diabetes in patients receiving renin blockers compared to other antihypertensive agents [relative risks=0.79; 95% confidence interval=0.75-0.84]. There was a statistically significant reduction in the incidence of new-onset diabetes in patients receiving renin-blockers compared to diuretics, conventional antihypertensive therapy [diuretics or beta-blockers], and calcium channel blockers. Renin blockers reduce the incidence of new-onset diabetes and should be considered as first line therapy, when indicated, in patients at high risk for diabetes

role of vitamin E in the prevention of coronary events and stroke. Meta-analysis of randomized controlled trials

Cardiovascular disease CVD is the leading cause of morbidity and mortality in the world. Vitamin E as an anti-oxidant vitamin, was suggested to have a role in the prevention of CVD. We did a meta-analysis, using the Cochrane Group Methodology, of all available randomized controlled trials RCTs to evaluate the role of vitamin E in the prevention of CVD. Nine studies met inclusion criteria, including 80,645 participants. Vitamin E supplementation was not associated with a reduction in total mortality or total CVD mortality, but it was associated with a small statistically significant reduction in non-fatal myocardial infarction in patients with pre-existing coronary artery disease. Prophylactic use of vitamin E in doses ranging between 50-800 IU was not associated with any increase in the incidence of serious side effects