Synthesis and pharmacological studies of 1, 3-disubstituted malonic acids

A new series of 1, 3-disubstituted malonic acid compounds [I-IX] were prepared via the reaction of malonyl di-chloride with the selected amino acids [P-alanine, glycine and aspartic acid] and their ethyl and propyl esters respectively. Structure of all the synthesized compounds have been elucidated by I.R. Synthesized compounds were found to be pharmacologically active and showed sedative-hypnotic activity and positive behavioral changes

Antibacterial and antifungal investigation of the root extracts of Croton sparciflorus

The present study was undertaken to find out the antibacterial and antifungal effects of crude organic extracts obtained from root of Croton sparciflorus. The crude organic extract was prepared from shade dried root of Croton sparciflorus by using petroleum ether, chloroform, ethyl acetate and alcohol 90%. The antibacterial and antifungal activities were tested on selected gram positive and gram negative bacteria and fungi. The chloroform, petroleum ether, ethyl acetate and alcohol extracts showed activity against Pseudomonas aeruginosa while chloroform extract showed activity against Bacillus subtilis and Escherichia coli. These extracts did not show any inhibitory activity against Candida albicans

Formulation and standardisation of Aegle marmelos suspension

Aegle marmelos suspension was prepared by using the leaf powder of Aegle marmelos. Before making the formulation, the leafy drug was authentified by suitable methods like physical, microscopical and chemical methods to confirm the standards. Thus subjected Aegle marmelos leaf powder was formulated as suspension with the help of suitable suspending agent and vehicle, and it was pharmacologically evaluated for anti-diabetic action. The prepared suspension significantly reduces blood glucose level in alloxan induced diabetes in rabbits