RESUMO
Background: Background: Non-small cell lung cancer [NSCLC] is the most common histologic form, leading causes of cancer death among masculine population. Half of CNPC was metastatic at diagnosis
Aim: To report the epidemiologic, anatomoclinic profile, therapeutic protocols and results of a retrospective study of non-small cell lung cancer [NSCLC] initially metastatic
Methods: our retrospective study include patients with NSCLC histologically confirmed with inaugural metastasis collected from January 1999 to december 2012. We had analysed epidemiologic, anatomopathologic data [TNM 2009], therapeutic protocols and results in term of overall survival, median survival and event free survival
Results: 100 case of NSCLC have been collected, mea nage was 57 years [22 to 81] and sex -ratio was 4,6. The majority of cases [74%] had a good performance statut [PS = 2]. Pathologic analysis leads to 81 cases of adenocarcinoma [ADK], 16 epidermoid carcinoma. 34% was stager T4 and 31% N2. Metastasis was located to bone in 36 cases, pleural in 26 cases, controlateral lung 26 cases, adrenal gland 17 cases and brain in 13 cases. 82% of patients underwent polychemotherapy as first line of treatment based on regimens conteined platine with mean number of 4 cycles. We have observed 4% of complete response, 61 of partial response, 20% of stabilisation, and 15% of progression. A palliatif radiotherapy of bone or brain metastasis was performed in 38% of cases. With a median follow-up of 71 months [12 to 130 months], mean survival was 11 months; overall survival [Kaplan-Meier] at 1, 3 and 5 years was respectively 44, 13 and 0%
Conclusion: Despite therapeutic progress in management of NSCLC, the prognosis of metastatic forms still reserved with a poor mean survival reported in litterature [12 years] valideted in our study. This push us to improve research mainly since advent of targeted therapy which still a promising way in the management of these tumors