RESUMO
Objective: Evaluation of single preoperative dose of pregabalin in terms of postoperative pain after laparoscopic cholecystectomy
Study Design: Randomized controlled trial [RCT]
Place and Duration of Study: Study was conducted in Surgical Department of Military Hospital Rawalpindi over a period of one year fromJan 2013 to Dec 2013
Material and Methods: One hundred patients [50 in each group] were included in this study. They were divided into two groups. Group-A was given pregabalin and group-B was given placeboafter laparoscopic cholecystectomy
Results: Mean age was 38.2 +/- 11.0 years in group A and 36.9 +/- 11.7 years in group B. Regarding distribution of gender, 14 patients [28.0 Percent] in group-A and 17 patients [34.0 Percent] in group-B were males while 36 patients [72.0 Percent] in group-A and 33 patients [66.0 Percent] in group-B were females. Mean visual analogue score at 24 hours was 4.98 +/- 1.87 and 6.58 +/- 2.03 in group-A and B, respectively. The difference between two group was statistically significant [p<0.001]. Analgesia was required in 17 patients [34.0 Percent] in group-A and 37 patients of group-B
Conclusion: A single preoperative oral dose of pregabalin 150 mg was found very effective method for reducing postoperative pain in patients undergoing laparoscopic cholecystectomy