study on the possible acute toxic interactions between digoxin and some cardiac drugs in mice

Digoxin-drug interactions are relatively common causes of digitalis toxicity. Cardiac patients receiving digoxin therapy are particularly prone to interactions with commonly co-administered medications such as amiodarone [antiarrhythmic] and nimodipine [calcium channel blocker].The aim of this study was to estimate intraperitoneal LD[50] of digoxin, nimodipine and amiodarone in male mice and to detect acute toxic interactions that could occur between digoxin and either nimodipine or amiodarone. It was concluded that LD[50] of digoxin, nimodipine and amiodarone were equal to 3.25 mg/kg, 13.2 mg/kg and 625 mg/kg respectively. Co-administration of LD[50], of digoxin with 1/4, 1/2 and I of LD[50] of nimodipine, reduced acute toxicity to 33%, 67% and 75% respectively. Meanwhile co-administration of digoxin with amiodarone produced acute toxicity equal to 75%, 100% and 100% respectively. A beneficial antagonistic toxic interaction had occurred on concomitant intraperitoneal administration of digoxin and nimodipine in mice meanwhile a synergistic toxic interaction had occurred between digoxin and amiodarone

Study of the acute toxicity of perosan [sodium peroxyborate]

Acute toxicity study was carried out for sodium peroxyborate [Perosan] on mice. The method of Litchfield and Wilcoxon was applied using the oral route. The compound possessed low toxicity and the LD50 was calculated to be 3562.5 mgm/kg. body weight

Effect of capsaicin on gastrointestinal absorption of acetaminophen

Capsaicin was shown in previous studies to affect the transport of some drugs across biological membranes. The present work aims at evaluating the effect of single doses of capsaicin on the gastrointestinal absorption of the widely used analgesic-antipyretic acetaminophen [paracetamol].The study was performed on adult male albino rats. Capsaicin was administered p.o. in the dose of 1 or 50 mg/kg simultaneously with acetaminophen [300 mg/Kg p.o.]. Acetaminophen plasma level were estimated. Capsaicin was shown to increase the gastrointestinal absorption of acetaminophen. The obtained changes in pharmacokinetic parameters are discussed in view of the works previously done concerning capsaicin and drug absorption