RESUMO
Background: Diabetes is one of the main causes of neuropathy. Metabolic control is essential to hinder its process. The present study was designed to investigate the effect of aerobics training on metabolic control in type-2 diabetic men with peripheral neuropathy
Methods: Twenty-four male subjects with Type 2 Diabetes were randomly assigned into two groups [each group comprised of 12 subjects]: 1- Aerobics training [43+/-6.4 yrs, 86.5+/-15.3 kg] 2- control [42+/-4.6 yrs, 89.3+/-11.9 kg]. Aerobics training consisted of 20 to 45 minutes walking and running with 50 to 75 percent of heart rate reserve, three sessions per week for 3 months. Before and 48h after last training session, body composition measurements were performed and then fasting and aftermeal blood samples were taken
Results: We observed no significant changes in weight, fat percentage and body mass index following intervention [P>0.05]. Furthermore, fasting and OGTT glucose and HbA1C levels significantly decreased and lipid profile improved significantly [P<0.05]. We also observed significant inter-group difference only for HbA1C and HDL-C [P<0.05]
Conclusion: Based on the findings of the present study, it could be concluded that aerobic exercise regimen could be a safe non-pharmacological strategy to achieve an optimal metabolic control in type-2 patients with peripheral neuropathy
RESUMO
Background: Apoptosis in skeletal muscle plays an important role in tissue dysfunction disease such as muscle atrophy. Current evidence suggests that exercise trainings may alter apoptosis-related signaling in skeletal muscle. Therefore, the present study was investigated the effect of 12 weeks of aerobic training on some indices of skeletal muscle apoptosis in rats
Methods: This study was conducted as a two-group experimental design on 20 randomly selected three month old male rats. Then divided them into two groups of training group [n=10] and control group [n=10]. Rats in training group participated in 12 weeks of aerobic training program. 48 hours after the last training session, the soleus muscle of rats in both group were isolated and Bax, Bcl2 and caspase-3 genes expression evaluated by Real Time-PCR
Results: The results indicated that there is a significant difference in gene expression of Bcl-2 [P< 0.01] and Bax to Bcl-2 ratio [P< 0.05] between control and training group. Furthermore, there was no significant difference between the two groups in expression of Bax and caspase-3 [P> 0.05]
Conclusion: The 12 weeks of aerobic training was effective in increasing skeletal muscle mitochondrial anti-apoptotic protein. However, considering the alterations of caspase-3 expression, more researches are needed to identify the effects of exercise training on skeletal muscle apoptosis
RESUMO
Background and Objectives: There is limited available data about the effects of antioxidant supplements on changes of hematological parameters after exercise. This study was carried out to investigate the effect of short-term CoenzymeQ10 supplementation on white blood cells, hemoglobin and red blood cell indices in non-athlete men after relatively intense running
Materials and Methods: Twenty healthy inactive men [25+/-3 years, fat 13+/-2. % and VO2max 41+/-2 ml/kg/min] in a randomized and double-blind design were allocated in two equal groups: supplement [2.5 mg/kg/day Coenzyme Q10] and placebo [2.5 mg/kg/day dextrose] groups. After the 14-day supplementation therapy, all subjects were participated in an aerobic exercise with 75% VO2max on the treadmill for 30 minutes. Blood samples obtained before the Q10 supplementation along with before and after the exercise protocol
Results: Ingestion 14-day coenzymQ10 supplementation on indexs [RBC, Hg, MCV, MCH, MCHC, Hct, WBC,PLT, lanphosit percentages, notrophils and other blood cells] had no significant effect [P>0.05] on basal parameters. Moreover, aerobic exercise causes lower red blood cells counts, hemoglobin and hematocrit and increase White blood cells and platelete [P<0.05], However, the rang of lower red blood cells, hemoglobin, hematocrit and increase white blood cells in supplementation group after aerobic exercise low was that placebo group [P<0.05]
Conclusion: Tngestion 14-day coenzymQ10 supplementation [with 2/5 g/kg/day] in effective on withe blood cells, hemoglobin and red blood cell indices after that aerobic exercise
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Caffeine is a well know substance with widely usage worldwide. Today some researches confirmed the conflicting effects of caffeine compound on cellular damage markers. The aim of this study was to determine the effect of different dosage of caffeine intake on some cellular damage markers in serum of male volleyball players after the one-single exhaustive resistance exercise. In a randomized double-blind design study, thirty elite male volleyball players [mean aged 21.47 +/- 1.45 years, fat percentage 10.47 +/- 3.11% and BMI 23.15 +/- 1.26 kg.m[2] were categorized to three equal groups: supplement groups [with 6 and 9 mg.kg[+1] caffeine] and placebo group [6 mg.kg[+1] dextrose]. After the supplementation, all subjects were participated in one-single-session of resistance weight-training [with 80% of one repetition maximum until exhaustive]. Changes in cellular damage indices [total serum CK, LDH and AST] were determined in three phases [Baseline, immediately and 24 hours after the training protocol]. The normal data were analyzed by repeated measure ANOVA and Bonferroni at alpha/=0.05]. Also, exhaustive resistance exercise significantly increased levels of 24-hour CK, LDH and AST in all groups [P/=0.05]. Based on the present findings, it could be concluded that acute intake of different doses of caffeine did not significantly prevent further damage- however it was not made the deterioration of the indirect indices of cell damage in compared with the placebo group
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The prevalence of obesity and its complications is rapidly increasing worldwide. Hence, the objective of this study was to determine the effects of 10 week progressive resistance training on serum levels of adiponectin and lipid profiles in obese men. In semi-experimental study, Sixteen obese men [Body Mass Index 0.05]. According to this study, resistance training because of anti-inflammatory and hypolipidaemic effects has been an effective therapeutic devise to favorable changes in lipid profiles and adiponectin levels in obese individuals