RESUMO
Objective: The objective of this study was to assess the diagnostic accuracy of most widely used serological test for diagnosis of celiac disease [CD] i.e. anti-tissue transglutaminase antibody [IgA] in comparison to histopathological lesions in CD,. Study Design: cross sectional study Place and Duration of Study: This study was carried out at the Departments of Gastroenterology and Pathology of Fatima Memorial Hospital, Shadman, Lahore fiom March 2014 to October 2014. Materials and Methods: 121 patients clinically suspected of celiac disease were included in this cross sectional study. The biopsy was taken from the second part of duodenum and was evaluated according to Marsh classification of CD. Blood sample of every patient was obtained to perform anti-tTG antibody test. Results: The range of the patients included in the study came out to be 18-65 years with 30.24 years as mean age. Out of all the patients included in this study 34 [28.1%] were males and 87[71.9%] were females. The overall sensitivity and specificity of anti-tTG were 78.6% and 98.1%.The positive predictive value [PPV] and negative predictive value [NPV] came out to be 84.6% and 97.2% rcspcctively. Conclusion: We have come to the conclusion that currently there is no serological test which can be used as a sole tool for the diagnosis of celiac disease. Relying on serological test will lead to missed diagnosis of CD especially those patients which have Marsh lesions of lesser degrees
RESUMO
To assess the natural history of Renal Disease in patients with Pre-eclampsia or Eclampsia. It was an observational study. This study was conducted simultaneously at two tertiary care hospitals: Fatima Memorial Hospital, l.ahore and Bhatti International leaching Hospital, Kasur from March 2009 to January 2011 women presented with pre-eclampsia or/ and eclampsia were consectively selected for the study fulfilling the inclusion criteria. A total number of 220 patients were eniolled in this study. All parameters required f'or the study were done carefully as blood pressure, proteinurla, renal function tests, urinary creatinine, weight, primary or multiparous, any previous history of pre-eclampsia. These parameters are checked at three and then six months post delivery. Among 220 patients, 140 [63.6%] were primigravida and 80 [36.4%] were multigravida. Blood pressure was from 140/90 to 210/110mmHg average blood pressure was 175100. 195 [8863%] patients had deranged renal function tests and 215 [97%] patients had protelnuria >2+. At Three months post-delivery 151[68.6%] patients achieved normal blood pressure and 190[86.3%] had normal serum creatinine i-e < 1.4. At six months 161 [73.8%] got adequate control of blood pressure, 59 [26.81%] had blood pressure > 140/90. Serum creatinine became in normal range in 195 [88.63%]. Acute renal failure was observed in 6 patents who weie put on renal replacement therapy