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Background : Scabies is a contagious intensely pruritic ectoparasitic infestation caused by mite Sarcoptes scabiei hominis. Various treatment modalities are available but topical permethrin and oral ivermectin is considered to be safe and effective in the treatment of scabies. Aim : To compare the efficacy of topical permethrin and oral ivermectin in the treatment of scabies. Material And Methods : It was an interventional study conducted in the out patient department Rohilkhand Medical College and Hospital.100 clinically diagnosed cases of scabies belonging to either sex and from 10-60 yrs of age were selected and divided into two groups. Oral ivermectin was given to group A and topical 5% permethrin was given to the group B and follow up at 1, 2 and 4 weeks of interval. at each visit and cure rate was compared. Results : Permethrin showed the efficacy of 89.1% in completely clearing scabietic lesions at 4 week interval as compared to oral ivermectin which showed 78.5% clearing of lesions in 4 weeks. Thus both the treatment modalities were almost equally effective. Conclusion : Oral ivermectin and topical permethrin both are almost equally effective but permethrine has rapid onset of action.
RESUMO
OBJECTIVE: To document clinical profile of cystic fibrosis (CF) in Indian children and the prevalence of delta F508 mutation in these patients. DESIGN: Observational study. Setting:Pediatric chest clinic in an urban tertiary care center in north India. PERIOD OF STUDY: July 1995 to June 2002. METHODS: Clinical features of 120 children diagnosed as CF by quantitative pilocarpine iontophoresis were recorded. A polymerase chain reaction based test for identification of delta F 508 mutation was performed on all children. RESULTS: Out of 3500 new cases registered in Pediatric Chest Clinic during this period 120, (3.5%) children were diagnosed as CF. Origin of parents of patients traced from almost all the States of north India. Family history suggestive of CF was present in 41 (34%) and consanguinity in 19 (61%) patients. Common clinical manifestations at the time of presentation included recurrent or persistent pneumonia in 118 (98%), failure to thrive in 108 (90%), malabsorption in 96 (80%), history of meconium ileus in 10 (8%), and rectal prolapse was present in 16 (13%). History of salt craving, salty taste on kissing and skin rashes was present in 5 patients each. 49(41%) patients were severely malnourished. Nasal polyposis was present in 5 (4%) patients. Examination of chest revealed evidence of hyperinflation in 100 (83%), kyphosis 20 (17%), crepitations 110 (92%), wheezing 40 (25%) and bronchial breathing in 20 (17%) patients. Average clinical CF scores were 51 (95%; CI 20-80). 48 (40%) patients had a CF score of LT40. Pseudomonas spp was cultured from respiratory secretions of 51 (42%), Staphylococcus spp in 18 (15%), Klebsiella spp in 8 (7%) and Hemophilus influenzae in 2 (2%) patients. Delta F508 mutation was positive in 45 chromosomes out of 240 tested. Patients originated from Pakistan had more frequency of delta F508 mutations. CONCLUSIONS: Cystic fibrosis does occur in Indian children; clinical features are classical. Diagnosis is often delayed and the disease is advanced in most patients at the time of diagnosis. Frequency of Delta F508 mutation is 19% i.e., less than that seen in Caucasian population. There is need to create awareness about occurrence of CF in Indian children.