RESUMO
Background: The genus Amaranthus has potential activity as a hepatoprotective agent. Objective: The present pharmacological investigation focuses on evaluation of the effi cacy of aqueous extract of roots of Amaranthus tricolor Linn. for their protection against paracetamol (PCM) overdose induced hepatotoxicity. Materials and Methods: The aqueous extract of roots of A. tricolor Linn. was prepared and phytochemical screening was done. The biochemical investigation viz. serum glutamic oxaloacetate transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and total Bilirubin (TB) was done against PCM-induced hepatotoxicity in wistar albino rats. The histopathological studies of liver were also done. Results: The phytochemical screening of the aqueous extract showed the presence of alkaloids, carbohydrates, fl avanoids, amino acids, proteins, fi xed oil, saponins and tannins, and phenolic compounds. Pretreatment with the aqueous extract of root signifi cantly prevented the physical, biochemical, histological, and functional changes induced by paracetamol in the liver. The extract showed signifi cant hepatoprotective effects as evidenced by decreased serum enzyme activities like SGPT, SGOT, ALP, and TB, which was supported by histopathological studies of liver. The aqueous extract showed signifi cant hepatoprotective activity comparable with standard drug silymarin as well as hepatotoxin drug PCM. Conclusion: From these results, it is concluded that the A. tricolor has potential effectiveness in treating liver damage in a dose dependent manner.