RESUMO
Resumen Las enfermedades cardiovasculares son la principal causa de muerte a nivel mundial y dentro de éstas se encuentra la enfermedad obstructiva de las arterias coronarias. El tratamiento más común para dicha enfermedad es la angioplastia con stent, que busca recuperar la luz de la arteria y revascularizar al paciente. Desde la aprobación del primer stent metálico la cardiología intervencionista ha experimentado un desarrollo continuo, impulsado por la necesidad de tener alternativas de tratamiento más seguras y eficaces. Dichos avances se reflejan en cuatro generaciones de stents liberadores de fármacos. El presente artículo busca describir las principales características de cada una de estas generaciones.
Abstract Cardiovascular disease is the leading cause of death worldwide and within these the coronary artery disease. The most common treatment for this condition is angioplasty with stent, which seeks to recover the lumen of the artery and revascularization the patient. Since the adoption of the first bare metal stent the area of interventional cardiology has experienced continuous development driven by the need for a safe and effective alternative treatment. These advances are reflecting in four generations of drug-eluting stents. This article aims to describe the main features of each of these generations.
RESUMO
Two laboratory methods for evaluating citric acid production ability by classical evaluation method using Petri dish with agar medium and pH indicator did not show good correlation with acid production by surface and submerged methods. Better correlation was observed when a horizontal tube method was compared with surface (r=0.550) and submerged (r=0.352) methods of citric acid production in synthetic medium. These results indicated that the tube method was superior to the Petri dish method for evaluation of the citric acid production potential of Aspergillus niger