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Medical Journal of Cairo University [The]. 2007; 75 (2 Supp.): 29-35
em Inglês | IMEMR | ID: emr-145636

RESUMO

Twenty five cases with acute lymphoblastic leukaemia were included in this study. They received induction, intensification and maintenance chemotherapy [Modified Berlin-Frankfurt-Munster BMP 76/79 Protocol], plus prophylactic cranial irradiation to a total dose of 1800 cGy/ 2 weeks/ 10 fractions. MRD quantification was done using real-time PCR. It was found that patients with negative MRD had much better overall and relapse-free survivals than those with positive one, 100% versus 20% and 100% versus 25% at the end of 24 months follow-up. Again, it was found that PCR-MRD levels > 0.01 or more can predict the relapse and the prognosis of those cases was much worse than those with lower levels


Assuntos
Humanos , Masculino , Feminino , Neoplasia Residual/terapia , Doença Aguda , Irradiação Craniana/estatística & dados numéricos , Criança , Resultado do Tratamento , Hospitais Universitários , Prognóstico
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