Anticardiolipin and anti beta 2 glycoprotein 1 in Omani patients with anti phospholipid syndrome

Anti-cardiolipin [ACA] and anti-beta 2 glycoprotein I [beta 2GP1] antibodies are thought to be involved in the development of arterial or venous thrombosis, thrombocytopenia and recurrent fetal loss. We examined the presence of these autoantibodies in Omani patients with autoimmune and non-autoimmune disorders. Sera from 30 patients with systemic lupus erythematosus [SLE; 30], 44 with a history of recurrent abortion and 36 with thrombosis/thromboytopeania were tested for ACA and anti-beta 2GP1 antibodies. In addition, sera from 30 healthy subjects were also tested for these antibodies. ACA were detected in 23% with SLE, 27% suffering from recurrent abortion and 36% of patients with thrombosis/thrombocytopenia while anti-beta 2GP1 antibodies were detected in 16.6%, 18% and 22% of same patients, respectively. Our data demonstrate a high prevalence of ACA and anti-beta 2GP1 antibodies of either combined or separate pattern among the Omani patient groups studied

Antimitochondrial autoantibodies in Omani patient with liver disease

Anti-mitochondrial autoantibodies [AMA] are important as a diagnostic marker in distinguishing primary biliary cirrhosis [PBC] from other liver problems. We performed a comparative study between enzyme-linked immunosorbant assay [ELISA] and immunofluorscence techniques [IF] for the detection of AMA in 40 Omani patients with liver diseases and 27 normal control subjects. Results showed that AMA in the patient's sera, detected by ELISA or IF, were significantly [p.<0.0001] higher than that found in normal control subjects. A significant difference [P