RESUMO
The purpose of the study is evaluation and assessment of parameters of cardiac toxicity in patients subjected to 5-FU based chemotherapy. Cardiac morbidity is a reported outcome in different 5FU/LV regimens; however none of them are definite or proximate. The bimonthly regimen of high dose leucovorin is reported to be less toxic and more effective as compared to the monthly regimen of low dose leucovorin. We report the detailed assessment of few cardiac parameter of toxicity in patients of advanced colorectal carcinoma subjected to two Schedules of high and low dose Folinic Acid, 5-Fluorouracil, bolus and continuous infusion. The correlation of elevated cardiac biomarkers, angina and hypertension is comparatively assessed in patients with normal general status, hyperglycemia and known cardiac disorders subjected to two different 5FU based chemotherapeutic regimen
Assuntos
Humanos , Feminino , Masculino , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Carcinoma/tratamento farmacológico , Hipertensão/induzido quimicamente , Leucovorina/efeitos adversos , Cardiopatias/induzido quimicamente , Fluoruracila/efeitos adversos , Biomarcadores/sangue , Pressão Sanguínea/efeitos dos fármacos , Estudos Prospectivos , Fatores de Risco , Fatores de Tempo , Resultado do TratamentoRESUMO
Background: Colorectal carcinoma is treated successfully with 5-fluorouacil and leucovorin in combination with oxaliplatin. Although, the major adverse effects with this combination [FOLFOX] are hematological and gastrointestinal, a few cases of cardiac adverse effects have also reported. The effects on serum markers of cardiac status are yet to be investigated
Objectives: The clinical study is designed to assess the effects on cardiac biomarkers and enzymes in patients of colorectal carcinoma undergoing chemotherapy
Methods: Thirty eight patients with histologically confirmed colorectal carcinoma, subjected to different schedules of oxaliplatin based chemotherapy [FOLFOX] were included in the study. The serum biomarkers were assessed after each alternate cycle of treatment and compared with the pretreatment value. The individual case of elevation in cardiac biomarkers [CPK, Tropinin I, LDL and TGS] beyond diagnostic risk level were also assessed
Results: CPK and Tropinin I levels were significantly altered in FOLFOX patients after alternate cycles of treatment. High level of TGS was reported in 48% of the patients in FOLFOX4 treatment arm
Conclusion: The CPK levels and Tropinin I levels were adversely affected in FOLFOX7 schedule
RESUMO
Malignant peripheral nerve sheath tumour [MPNST] is a very rare tumour with an incidence of one per 100,000 and constitutes between 3 to 10% of all soft tissue sarcomas. Most of the sarcoma involve the extremities and retroperitoneal regions. However, this case presented with mass in left inguinal region and then spread rapidly to omentum, assuming the appearance of an omental cake. Mass responded well to chemotherapy comprising of Ifosfamide and Doxorubicin