Typhoid fever with hepatic and extrahepatic manifestations

Hepatic involvement is not uncommon in typhoid fever. We report a case of typhoid fever complicated by acute hepatitis, acute choliangitis, acute acalculous cholecystitis, anaemia and severe thrombocytopenia [platelets 1x10[3]/ul]. He received antibiotics, steroids, immunoglobulin, multiple platelet and packed RBC transfusion. Fever responded and blood parameters started improving after 16th day of the treatment and patient was discharged healthy on 21st day of the admission. In conclusion, hepatic dysfunction with jaundice is a serious development in typhoid fever and patient may take longer time to respond to treatment