prognostic value of phosphohexose isomerase in childhood leukemia and lymphomas

Serum phosphohexose isomerase [P.H.I.] activity was measured in 12 children suffering from acute lymphoblastic leukemia [A.L.L.], 8 children having acute nonlymphoblastic leukemia [A.N.L.L.], 17 children suffering from non-Hodgkin's lymphoma [N.H.L.] and 20 aparently healthy children of comparable age and sex as controls. Significantly increased activity of P.H.I. was observed in children with leukemias and lymphomas compared to controls. Children with A.N.L.L. had significantly higher P.H.I. activity than those with A.L.L. Follow up of the children during various stages of therapy showed significant decrease of P.H.I. after induction of remission. The levels were evidently elevated again several months before clinical and/or hematological relapses. It could be concluded that P.H.I. can be helpful adjuvant marker in childhood leukemias and lymphomas. Also, it can of therapy and to detect the early relapse

Maternal and neonatal blood glycosylated hemoglobin with maternal diabetes

The study included 35 newborns of diabetic mothers. They were subjected to full clinical examination including maternal history of abortion and the mode of delivery, signs of hypoglycemia, respiratory distress, jaundice and birth weight. The blood sugar in newborns, glycosylated hemoglobin [HbA[1c]] were done to all cases. Also maternal blood sugar and HbA[1c]] were done. A significantly higher maternal blood sugar and HbA[1c] than controls were found indicating the poor control of diabetes in the last two months of pregnancy. Also there was positive correlation between maternal and infant HbA[1c]. This may reflect the state of metabolic changes in diabetes. Significantly higher newborn HbA[1c] in cases with signs of hypoglycemia was observed in our I.D.M. A significantly lower newborn blood sugar was found in cases with history of repeated abortion, cases with hypoglycemic signs and cases with history of R.D. were found