Have magnesium sulfate, acetic acid, meprobamate and fluoxetine an anti-arthrogenic activity?

Atherosclerosis is a progressive inflammatory disorder of the arterial wall that is characterized by focal lipid rich deposits of atheroma with possible correlation with sedative hypnotics in decreasing atherogenesis. This study was performed in Al-Kadhimiya teaching hospital from February 2009 to June 2009 on sixty healthy males who were allocated to six groups. Each group was given one of the following agents: Magnesium sulfate [MgSo4], acetic acid, Meprobamate, Fluoxetine in addition to Simvastatin and water. Clinical manifestations like [arterial blood pressure, radial pulsation], lipid profiles [serum cholesterol, triglycerides, HDL, LDL and VLDL] total free radicals and platelets function tests are the parameters used in this study. All the tested agents reduce both the serum cholesterol concentration and total blood free radicals significantly; also they decrease both platelet count and adhesion test significantly. Both MgSo4 and Meprobamate lowered blood pressure and serum triglyceride concentration significantly, at the same time HDL concentration significantly changed by Fluoxetine when these parameters measured before and after treatment for 15 days. MgSo4, acetic acid, Meprobamate and Fluoxetine were found to have anti-arthrogenic activity and the possibility to be used clinically in atherosclerosis

Role of surgery and laparoscopy in management of abdominal tuberculosis

Tuberculosis [TB] considered as the most communicable disease world wid. Among extra pulmonary TB the prevalence of abdominal TB shows rising tendency. Abdominal TB is defined as an infection of one or more common of two or more of the following sites; peritoneum, mesentery, gastrointestinal tract and or solid organs. Reported incidence of abdominal TB varies from country to country. The most common clinical features are abdominal pain, fever and weight loss. To evaluate the role of surgery in the management of abdominal TB especially with the advent of minimal access surgery [laparoscopy] in the diagnosis of this disease. Prospective study was conducted in Al-Kadhymia Teaching Hospital over three years [2007-2010], fifty six patients with abdominal TB were included, the patients were managed by full surgical and or medical teams, results was analyzed by appropriate statistical measures. Most patients were in the 2[nd], 3[rd] and 4[th] decades of life. Female to male ratio was 1.5:1. Most of the patients [82%] considered to have primary abdominal TB. Diagnostic laparoscopy was done for 21 patients and proved TB in 19 patients. Explorative laparotomy was done in 19 patients, the commonest operative finding was ascites and peritoneal tubercles. Abdominal TB should be considered in all patients who presented with unexplained abdominal symptoms and signs. Laparoscopy is an effective modality for diagnosis of abdominal TB