RESUMO
Activin is a growth and differentiation factor of many cell types and has recently been implanted in inflammatory processes. Clinical data demonstrating roles of activin and its antagonist inhibin in inflammatory arthropathies, are lacking. The Study is to measure serum and synovial fluid levels of activin A and inhibin A in patients with rheumatoid arthritis [RA] systemic lupus erythematosus [SLE] and osteoarthritis [OA] and correlate them with disease activity parameters. This study included 60 patients with three rheumatic diseases [20 with RA, 20 with SLE and 20 with OA], as well as ten healthy subjects as a control group. All of them were subjected to complete history, physical and musculoskeletal examination and estimation of disease activity index [DAS- 28] for RA and [SLEDAI] for SLE. The following investigations were done for all subjects; serum and synovial activin A and inhibin A; in addition to complete blood picture, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP],rheumatoid factor [RF], antinuclear antibodies [ANA],anti-dsDNA, serum complement [C 3, 4] and Xrays on affected joints. The mean values of serum activin A were significantly higher in RA, SLE and OA than controls [P<0.001] also in RA and SLE versus OA [P<0.05 for both]. The mean values of serum inhibin A were significantly higher in all studied groups than controls [P<0.05 for RA and OA and P<0.001 for SLE]. Also serum inhibin levels were significantly higher in SLE versus OA P<0.001, but there was no significant differences between RA and SLE. Synovial fluid activin and inhibin A were significantly higher in RA than OA [P<0.05 for both]. Positive correlations were found between serum activin A and disease activity parameters of RA morning stiffness [MS], Ritchie index [RI], ESR, CRP and DAS 28] P<0.05, for all. Also positive correlation was found between serum inhibin A and RI in RA patient [P<0.05]. In SLE, positive correlations were found between serum activin A and inhibin A with ESR [P<0.001 for activin and P<0.05 for inhibin A and SLEDAI [P<0.001 for both activin and inhibin]. No correlation were found between synovial activin and disease activity and negative correlation between synovial inhibin and ESR. The significant increase of serum and synovial activin A and inhibin A in RA and SLE and their positive correlations with disease activity parameters of RA and SLE suggest pro-inflammatory action. However the lack of correlations or negative correlation of their synovial levels with disease activity may indicate their anti inflammatory action, We recommended further studies to detect the exact role of activin A and inhibin A
Assuntos
Humanos , Masculino , Feminino , Ativinas/sangue , Inibinas/sangue , Líquido Sinovial , Sedimentação Sanguínea , Proteína C-Reativa/sangue , Fator Reumatoide/sangue , Anticorpos Antinucleares/sangue , Complemento C3cRESUMO
Cytokines control myeloma cell proliferation, differentiation, apoptosis and tumor-induced bone marrow destruction. The present study was designed to estimate the serum levels of interleukin-6 [IL-6], soluble IL-6 receptor [sIL-6R], IL-1 beta, tumor necrosis factor-alpha [TNF-alpha], and beta-2 microglobulin [beta 2M] in multiple myeloma [MM] in an attempt to elucidate their role in the disease, to study their levels in different immunologic types of MM, and to evaluate the effect of therapy on these levels. The study included 40 patients with MM, 20 newly diagnosed [group I] and 20 patients receiving treatment [group II]. Ten patients received therapy for
Assuntos
Humanos , Masculino , Feminino , Citocinas , Interleucina-6 , Fatores de Necrose Tumoral , Interleucina-1 , Receptores de Interleucina-6 , Microglobulina beta-2 , Prognóstico , Eletroforese das Proteínas SanguíneasRESUMO
This study revealed a significant reduction of insulin mean values in all diabetic patients. The reduction was more significant in vascular- complicated NIDDM than complicated and in vascular- complicated patients with more than five years disease duration compared with non- vascular complicated patients. Glucagon mean values showed a significant reduction in patients with positive family history, those with less than five years disease duration and in NIDDM patients compared with controls. The vascular complicated IDDM patients showed a significant reduction of the mean level of ACT compared with non-vascular group. Significantly increased mean levels of growth hormone were found in all groups compared with the controls. Significant elevation of prolactin level was observed comparing negative and positive family history and comparing vascular and non- vascular complicated NIDDM patients. Significant reduction of IGF-1 levels was found comparing diabetic patients with controls, patients with less and more than five years disease duration with controls and with those with less than five years duration and comparing IDDM with controls or with NIDDM patients