Impact of preoperative endoscopic biliary drainage on the outcome of patients undergoing whipple's operation for periampullary carinomas

Fifty patients with obstructive jaundice due to periampullary carcinomas who are candidates for surgical resection were selected for this study. They were 31 males [62%] and 19 females [38%] with mean age 55.5 years, range from 32 to 70 years. After preoperative work up for assessment of the operability and fitness for operation all patients were subjected to pancreaticoduodenectomy after randomization into 2 groups. Group [A] included 25 patients subjected to the operation without preoperative endoscopic biliary drainage and group [B] included 25 patients subjected to the operation after preoperative endoscopic biliary drainage.Hospital mortality occurred in 3 patients [6%], 14 patients [28%] developed complications. The average hospital stay was 10.2 days differences between the two groups were evaluated statistically. We concluded that preoperative biliary drainage should be reserved only for patients in whom surgery with intent for cure has to be postpond and in patients with border line resectable tumours requiring downstaging protocol

study of Helicobacter pylon in dyspeptic patients with and without decompanseated liver disease

Helicobacter pylori infection was investigated by two different methods, microscopically and biochemically in 200 dyespeptic patients [149 male and 51 female] aged from 40-70 years. All patients divided into two groups, the first one as control group [100] and without liver cell failure, the second studied group [100] as diseased group with liver cell failure. Helicobacter pylori infection was diagnosed in 54% in the first group and 78% in the second group. The Helicobacter pylori prevalence in the second group of liver cell failure was significantly higher than in the first control group and was not correlate to the sex difference, etiology of the liver cell failure, child classification or any endoscopic finding of gastroduodenal mucosal lesion. In both groups Helicobacter pylori infection was significantly higher in patients over 40

Study of interleukin-6 and interleukin-8 in Egyptian patients with chronic liver disease due to hepatitis C and bilharziasis

In this study, the serum levels of previous cytokines IL-6 and IL-8 were measured in 60 patients and 20 controls by ELISA technique. The patients were classified into group A [20] cases with type C-CAH, group B [20] cases with mixed pathology type C-CAH and bilharziasis which was subdivided into group B1 [ten cases with active bilharziasis] and group B2 [ten cases with inactive bilharziasis] and group C [20 cases with hepatic cirrhosis which was subdivided into group C1 and group C2]. The results have shown that there was a statistical difference of serum levels of IL-8 in group B1 in comparison with group B2, while there was a change in IL-6 in group B1 in comparison with group B2. Also, there was a statistical difference of serum level of IL-6 and IL-8 in group C1 in comparison with group C2. It was concluded that viral specific activated T-cell response occurred in type C- CAH with or without bilharziasis with subsequent release and elevation of proinflammatory and protective cytokines such as IL-6 and IL-8. Also, this increase of previous cytokines was related to the degree of HCV activity

Effects of occupational exposure to lead on neurological and neurophsyiological functions among printing workers

This study was designed to evaluate the neurological and the neurohysiological effects of chronic lead exposure. A group of printing workers exposed to inhalation, ingestion and skin absorption of lead, consisting of 47 subjects, as well as a control group from the non-exposed administrative subjects were included. This study was designed to evaluate the neurological and the neurophysiological effects of chromic lead exposure. A group of printing workers exposed to inhalation, ingestion and skin absorption of lead, consisting of 47 subjects, as well as a control group from the nonexposed administrative subjects were included. All subjects were submitted to assessment of exposure profile, general and neurological history and examination, blood lead concentration, blood picture, and a selected battery of neurophysiological investigations. Among exposed workers compared to controls, we detected a significantly higher prevalence 9% headache, fatigability, muscle weakness, numbness and tingling sensations and significantly higher blood lead levels and lower hemoglobin levels. The electro physiological studies showed significant motor and sensory slowing of nerve conduction velocities [NCVs], lowering of amplitudes, and prolongation of distal latencies both median and ulnar nerves of the exposed workers versus control subjects. Abnormalities of electromyograpnhy [EMG] in the form of neurogenic polyphasic waves during ' minimal muscle contraction and spontaneous activities were recorded in 91.7% and 16.7% respectively among exposed workers