comparison of the prevalence of anti-liver/kidney microsome antibody type-1[LKM-1] in individuals with chronic hepatitis C and those with autoimmune hepatitis

Autoantibodies are frequently found in patients with chronic hepatitis C, which suggests that HCV elicit an immune response in the host]. The relationship of type-2 AIH to chronic hepatitis C [HCV] is an interesting and as yet unresolved problem. Importantly, antibodies to liver/kidney microsome type- I [LKMI], the serologic marker of type 2-AIH, have been recognized in serum of some patients with chronic hepatitis C. Anti-liver kidney microsome type 1 [LKM-1] autoantibodies were studied by indirect immuno florescence assay [lIF] and confirmed by immunoblot in the serum of 73 Iraqi patients with autoimmune hepatitis [AIH] in comparison with 50 patients control [HCV infection] and 50 healthy individuals. anti-LKZM 1 with high titers [>/= 1/160] present in serum of al/patients with AIH-2, whereas they present in titer [

Significance of serum pepsinogens in atrophic gastritis

Chronic atrophic gastritis is a precancerous lesion. A commonly used test for the diagnosis of chronic atrophic gastritis, gastric endoscopy with biopsy collection, and a good serological test would be best include low levels of pepsinogen I [PGI] or a low PGI/PGII ratio. To confirm the use of serum pepsinogens as a screening marker in atrophic gastritis. A study was conducted in the period between December 2005 and March 2006 on 25 patients with artophic gastritis attending Gastroenterology and Hepatology Teaching Hospital in Baghdad, and 25 healyh control subjects. Sera were tested for PGI and PGII by ELISA test the serum PGI were decreased significantly with artophic gastritis and the PGI/PGII ratio were decreased in [78%] of patient group and not affected in healthy people