RESUMO
Objective: To describe the demographic and clinical features of females presenting with breast malignancies at the Shaukat Khanum Memorial Cancer Hospital and Research Center [SKMCH and RC], Lahore, Pakistan
Study Design: An observational study
Place and Duration of Study: SKMCH and RC, Lahore, from January 2008 to December 2012
Methodology: Demographic and clinical features of female breast cancer patients, registered at SKMCH and RC, were studied. Mean values, counts, and percentages were obtained
Results: Four-thousand, three-hundred and sixty-six female breast malignancies were recorded. Nearly 80.4% of the patients belonged to Punjab. Mean age at presentation was 48.6 +/- 12.2 years, at menarche was 13.2 +/- 1.2 years, and at first childbirth was 23.7 +/- 4.8 years. Mean Body Mass Index [BMI] was 29.0 +/- 5.7 kg/m[2]. In 60.1%, history of breast feeding was positive. In 55.7%, there was no history of use of any Oral Contraceptive Pills [OCP]/Hormone Replacement Therapy [HRT]. Nearly 42.7% were postmenopausal, 85.2% had infiltrating ductal carcinoma, 49.6% had grade 3 tumor, 60.7% had stage II disease, and 37.3% were Estrogen Receptor [ER]/Progesterone Receptor [PR]+, Human Epidermal Growth Factor Receptor 2 [HER2]-. Family history of breast cancer was positive in 16.9% of the cases
Conclusion: The mean presenting age is lower than what has been recorded in the West. It may be worthwhile collating results from different institutions in order to study the epidemiology of the disease more extensively and develop cancer control and early detection programs