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ObjectiveTo observe the variation in content of vascular endothelial growth factor （VEGF） in patients with Alzheimer's disease （AD） and to investigate efficacy of Yangxue Qingnao granule on AD and the effect on VEGF. MethodA total of 60 patients with cognitive impairment ［30 of AD and 30 of amnestic mild cognitive impairment （aMCI）］ were selected， and another 30 healthy people with Montreal Cognitive Assessment （MoCA）≥26 and age， gender， and complications insignificantly different from the patients were included as healthy control. The venous blood of aMCI group， AD group， and the healthy control group was collected at the enrollment to measure the level of serum VEGF. Then， the aMCI and AD patients were randomized into the observation group and the control group， with 30 patients in each group. The control group was given Donepezil Hydrochloride （5 mg·d-1）， while the observation group received Donepezil Hydrochloride （5 mg·d-1） and Yangxue Qingnao granule. MoCA was used to evaluate the severity of cognitive impairment. After the treatment for 6 months， the clinical efficacy and adverse reactions of the two groups were compared， and the serum VEGF levels were detected again by enzyme-linked immunosorbent assay （ELISA）. ResultThe serum content of VEGF in AD patients was significantly lower than that in aMCI patients and healthy people （P<0.05）. Serum VEGF levels in aMCI patients were significantly decreased compared with those in healthy people （P<0.05）. After treatment for 6 months， the serum VEGF level in the observation group was significantly higher than that before treatment， and was higher than that in the control group （P<0.05）. MoCA scores in the observation group were higher than those in control group （P<0.05）. The incidence of adverse reactions was insignificantly different between both groups. ConclusionThe serum levels of VEGF significantly decreased in aMCI and AD patients， suggesting that angiogenesis might be involved in the pathophysiological process of AD and correlated with the early stage of AD. Yangxue Qingnao granule， as a safe adjuvant therapy， showed ideal effect on aMCI and AD， as manifested by the improvement of cognitive function. The mechanism is the likelihood that it can elevate the expression of angiogenic factors such as VEGF， promote angiogenesis， and then improve the microcirculation of cortex.
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Objective:To explore the effect of situational simulation interactive training on rehabilitation compliance and motor function of stroke patients with hemiplegia.Methods:A total of 140 hemiplegic patients with stroke from July 2017 to October 2019 in Beijing Rehabilitation Hospital Affiliated to Capital Medical University were selected and divided into control group and observation group, 70 cases in each group. Routine treatment and rehabilitation nursing were used in the control group, and situational simulation interactive training were used in the observation group on the basis of the control group. Both groups were followed up for 6 months. Fugl-Meyer Assessment (FMA), World Health Organization Quality of Life Scale Brief (WHOQOL-BREF), Fugl-Meyer Assessment (FMA), self-made rehabilitation training compliance questionnaire and self-made nursing satisfaction questionnaire were used to evaluate the quality of life, motor ability, cognitive ability before intervention and after follow-up, rehabilitation compliance and nursing satisfaction after follow-up of the two groups.Results:There was no significant difference in FMA, WHOQOL-BREF and MMSE scores between the two groups before intervention ( P>0.05). After follow-up, the scores of FMA, WHOQOL-BREF and MMSE in the observation group were 62.57±6.52, 80.65±9.25, 25.30±3.24, significantly higher than 52.68±7.23, 66.68±8.34, 20.36±3.12 in the control group, the difference was statistically significant ( t value was 8.499, 9.385,9.189, P<0.05). After follow-up, the total compliance rate and satisfaction rate of the observation group were 92.86% (65/70) and 94.29% (66/70), respectively, while those of the control group were 78.57% (55/70) and 80.00% (56/70), respectively, the difference between the two groups was statistically significant (Fisher's exact test, P<0.05). Conclusions:The situation simulation rehabilitation training can effectively improve the motor function, rehabilitation compliance and nursing satisfaction of stroke patients with hemiplegia.
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Objective@#To investigate the effects of traditional rehabilitation training, motor relearning and transcranial direct current stimulation on FMA,ARAT score and ADL of stroke patients.@*Methods@#Sixty-five patients with initial stroke who were admitted to Rehabilitation center of Beijing rehabilitation hospital from August 2016 to August 2018 were selected. All the patients were randomly divided into two groups: the control group and the experimental group. On this basis, the experimental group received transcranial direct current stimulation for 6 weeks, while the control group received only false stimulation. The arm motion survey test scale (ARAT) and the simplified fugl-meyer motor function scale (FMA) were used to evaluate the upper limb motor function of patients, and the modified Barthel index scale (MBI) was used to evaluate the daily living activity ability of patients.@*Results@#There was no significant difference in FMA score, ARAT score and MBI score before and after treatment between the two groups (P > 0.05). After treatment, FMA and ARAT scores of the upper limbs in the experimental group were (39.44±4.09) and (18.92±3.28), respectively, while those in the control group were (34.22±4.20) and (15.30±3.22), respectively. The differences between the two groups were statistically significant (t=3.239, 2.939, all P < 0.05).@*Conclusion@#Traditional rehabilitation training, exercise relearning combined with transcranial direct current stimulation (TDCS) for stroke patients improved the upper limb motor function to some extent, and effectively improved the daily living ability of the patients. It is worth popularizing in clinic.
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Objective To investigate the effects of traditional rehabilitation training, motor relearning and transcranial direct current stimulation on FMA,ARAT score and ADL of stroke patients. Methods Sixty_five patients with initial stroke who were admitted to Rehabilitation center of Beijing rehabilitation hospital from August 2016 to August 2018 were selected. All the patients were randomly divided into two groups: the control group and the experimental group. On this basis, the experimental group received transcranial direct current stimulation for 6 weeks, while the control group received only false stimulation. The arm motion survey test scale (ARAT) and the simplified fugl_meyer motor function scale (FMA) were used to evaluate the upper limb motor function of patients, and the modified Barthel index scale (MBI) was used to evaluate the daily living activity ability of patients. Results There was no significant difference in FMA score, ARAT score and MBI score before and after treatment between the two groups (P > 0.05). After treatment, FMA and ARAT scores of the upper limbs in the experimental group were (39.44 ± 4.09) and (18.92 ± 3.28), respectively, while those in the control group were (34.22 ± 4.20) and (15.30±3.22), respectively. The differences between the two groups were statistically significant (t=3.239, 2.939, all P < 0.05). Conclusion Traditional rehabilitation training, exercise relearning combined with transcranial direct current stimulation (TDCS) for stroke patients improved the upper limb motor function to some extent, and effectively improved the daily living ability of the patients. It is worth popularizing in clinic.
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@#The core symptoms of Parkinson's disease include motor symptoms and non-motor symptoms. For the motor symptoms, the rehabilitation includes the basic training of joints, gait training, the training of core muscle group and posture balance, the training of oral, facial, neck muscle and pharyngeal reflex, the training of lip movement, vocalization, sound volume, rhythm and speed, and the training of deep breathing exercises and abdominal pressure. For the non-motor symptoms, the rehabilitation includes the training of memory, attention, problem solving ability, activities of daily living and others, psychotherapy, family support, social participation, and other comprehensive treatments combined with medicine.