RESUMO
Fifty children divided into 3 groups were studied. Group I included 10 children with recent onset diabetes type I [<6 months]. Their ages ranged from 6-11 years. Group II consisted of 20 children with prolonged diabetes [>5 years] aged 12-15 years. Twenty non-diabetic children aged 6-15 years represented group lll. All studied children were not suffering from any other autoimmune disorder, nor receiving a medication, which is known to affect any of the studied parameters. All children were subjected to detailed history taking, thorough clinical examination and venipuncture while fasting to measure HBA[1c], fasting insulin and antiphospholipid antibodies [APA] [lgG and 1gM]. It was found that duration of diabetes carries on a more significant effect on both SBP and DBP than the diabetes per Se. WHR reached risky levels [>0.8 in girls and>0.9 in boys] in 30% of children with recent onset diabetes, while BMI reached risky levels [>25 kg/m[2]] in only 10% of them. Fifty percent of children with prolonged diabetes [>5 years] had risky high WHR, while only 30%of them had risky high BMI. So, WHR, was found to be a more sensitive risk factor than BMI. Fasting insulin [Fl] levels were significantly lower in all diabetic children [with recent onset and with prolonged disease duration] than in non diabetic children [mean 3.8, 5.2 and 11.45 uU/ml respectively]. F! was found to be significantly affected by APA [lgG] and BP percentiles [P=0.002 and 0.048 in order]. APA [lgG] was significantly higher in 60%of children with recent onset diabetes, and only in 45% of those with diabetes for>5 years [mean 12.39 and 9.72 GPL/ml respectively]. APA [IgM] showed a less marked increase with diabetes, with high levels in only 20% of recent onset diabetics and 5% of those with prolonged diabetes [mean 8.52 and 6.945 MPL/ml respectively]. APA levels [lgG and 1gM] were affected significantly by WHR, BP percentiles and HBA[1c]. APA especially IgG can be added to the diagnostic autoantibodies of type I diabetes and WHR and BP percentiles to the control regimen [along with HBA[1c]] among children with type I diabetes